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Molecular identity of proprioceptor subtypes innervating different muscle groups in mice

Author

Listed:
  • Stephan Dietrich

    (Max-Delbrück-Center for Molecular Medicine)

  • Carlos Company

    (Max-Delbrück-Center for Molecular Medicine)

  • Kun Song

    (Southern University of Science and Technology)

  • Elijah David Lowenstein

    (Max-Delbrück-Center for Molecular Medicine
    NeuroCure Cluster of Excellence)

  • Levin Riedel

    (Max-Delbrück-Center for Molecular Medicine)

  • Carmen Birchmeier

    (Max-Delbrück-Center for Molecular Medicine
    NeuroCure Cluster of Excellence)

  • Gaetano Gargiulo

    (Max-Delbrück-Center for Molecular Medicine)

  • Niccolò Zampieri

    (Max-Delbrück-Center for Molecular Medicine)

Abstract

The precise execution of coordinated movements depends on proprioception, the sense of body position in space. However, the molecular underpinnings of proprioceptive neuron subtype identities are not fully understood. Here we used a single-cell transcriptomic approach to define mouse proprioceptor subtypes according to the identity of the muscle they innervate. We identified and validated molecular signatures associated with proprioceptors innervating back (Tox, Epha3), abdominal (C1ql2), and hindlimb (Gabrg1, Efna5) muscles. We also found that proprioceptor muscle identity precedes acquisition of receptor character and comprise programs controlling wiring specificity. These findings indicate that muscle-type identity is a fundamental aspect of proprioceptor subtype differentiation that is acquired during early development and includes molecular programs involved in the control of muscle target specificity.

Suggested Citation

  • Stephan Dietrich & Carlos Company & Kun Song & Elijah David Lowenstein & Levin Riedel & Carmen Birchmeier & Gaetano Gargiulo & Niccolò Zampieri, 2022. "Molecular identity of proprioceptor subtypes innervating different muscle groups in mice," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34589-8
    DOI: 10.1038/s41467-022-34589-8
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    References listed on IDEAS

    as
    1. Katherine M. Oliver & Danny M. Florez-Paz & Tudor Constantin Badea & George Z. Mentis & Vilas Menon & Joriene C. Nooij, 2021. "Molecular correlates of muscle spindle and Golgi tendon organ afferents," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    2. Nikhil Sharma & Kali Flaherty & Karina Lezgiyeva & Daniel E. Wagner & Allon M. Klein & David D. Ginty, 2020. "The emergence of transcriptional identity in somatosensory neurons," Nature, Nature, vol. 577(7790), pages 392-398, January.
    3. Haohao Wu & Charles Petitpré & Paula Fontanet & Anil Sharma & Carmelo Bellardita & Rolen M. Quadros & Paulo R. Jannig & Yiqiao Wang & J. Alexander Heimel & Kylie K. Y. Cheung & Simone Wanderoy & Yang , 2021. "Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
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