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Molecular correlates of muscle spindle and Golgi tendon organ afferents

Author

Listed:
  • Katherine M. Oliver

    (Columbia University Medical Center
    Columbia University Medical Center)

  • Danny M. Florez-Paz

    (Columbia University Medical Center
    Columbia University Medical Center)

  • Tudor Constantin Badea

    (National Eye Institute
    Transylvania University of Brasov, Faculty of Medicine)

  • George Z. Mentis

    (Columbia University Medical Center
    Columbia University Medical Center
    Columbia University Medical Center)

  • Vilas Menon

    (Columbia University Medical Center)

  • Joriene C. Nooij

    (Columbia University Medical Center
    Columbia University Medical Center)

Abstract

Proprioceptive feedback mainly derives from groups Ia and II muscle spindle (MS) afferents and group Ib Golgi tendon organ (GTO) afferents, but the molecular correlates of these three afferent subtypes remain unknown. We performed single cell RNA sequencing of genetically identified adult proprioceptors and uncovered five molecularly distinct neuronal clusters. Validation of cluster-specific transcripts in dorsal root ganglia and skeletal muscle demonstrates that two of these clusters correspond to group Ia MS afferents and group Ib GTO afferent proprioceptors, respectively, and suggest that the remaining clusters could represent group II MS afferents. Lineage analysis between proprioceptor transcriptomes at different developmental stages provides evidence that proprioceptor subtype identities emerge late in development. Together, our data provide comprehensive molecular signatures for groups Ia and II MS afferents and group Ib GTO afferents, enabling genetic interrogation of the role of individual proprioceptor subtypes in regulating motor output.

Suggested Citation

  • Katherine M. Oliver & Danny M. Florez-Paz & Tudor Constantin Badea & George Z. Mentis & Vilas Menon & Joriene C. Nooij, 2021. "Molecular correlates of muscle spindle and Golgi tendon organ afferents," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-21880-3
    DOI: 10.1038/s41467-021-21880-3
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    Cited by:

    1. Qian Li & Ting Tan & Benlong Wang & Zhimiao Yan, 2024. "Avian-inspired embodied perception in biohybrid flapping-wing robotics," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Stephan Dietrich & Carlos Company & Kun Song & Elijah David Lowenstein & Levin Riedel & Carmen Birchmeier & Gaetano Gargiulo & Niccolò Zampieri, 2022. "Molecular identity of proprioceptor subtypes innervating different muscle groups in mice," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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