Structural basis for the activation of the lipid scramblase TMEM16F
Author
Abstract
Suggested Citation
DOI: 10.1038/s41467-022-34497-x
Download full text from publisher
References listed on IDEAS
- Jun Suzuki & Masato Umeda & Peter J. Sims & Shigekazu Nagata, 2010. "Calcium-dependent phospholipid scrambling by TMEM16F," Nature, Nature, vol. 468(7325), pages 834-838, December.
- Luca Braga & Hashim Ali & Ilaria Secco & Elena Chiavacci & Guilherme Neves & Daniel Goldhill & Rebecca Penn & Jose M. Jimenez-Guardeño & Ana M. Ortega-Prieto & Rossana Bussani & Antonio Cannatà & Gior, 2021. "Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia," Nature, Nature, vol. 594(7861), pages 88-93, June.
- Tristan Bepler & Kotaro Kelley & Alex J. Noble & Bonnie Berger, 2020. "Topaz-Denoise: general deep denoising models for cryoEM and cryoET," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
- Janine D. Brunner & Novandy K. Lim & Stephan Schenck & Alessia Duerst & Raimund Dutzler, 2014. "X-ray structure of a calcium-activated TMEM16 lipid scramblase," Nature, Nature, vol. 516(7530), pages 207-212, December.
- Cristina Paulino & Valeria Kalienkova & Andy K. M. Lam & Yvonne Neldner & Raimund Dutzler, 2017. "Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM," Nature, Nature, vol. 552(7685), pages 421-425, December.
- Trieu Le & Zhiguang Jia & Son C. Le & Yang Zhang & Jianhan Chen & Huanghe Yang, 2019. "An inner activation gate controls TMEM16F phospholipid scrambling," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
- Young Duk Yang & Hawon Cho & Jae Yeon Koo & Min Ho Tak & Yeongyo Cho & Won-Sik Shim & Seung Pyo Park & Jesun Lee & Byeongjun Lee & Byung-Moon Kim & Ramin Raouf & Young Ki Shin & Uhtaek Oh, 2008. "TMEM16A confers receptor-activated calcium-dependent chloride conductance," Nature, Nature, vol. 455(7217), pages 1210-1215, October.
- Maria E. Falzone & Zhang Feng & Omar E. Alvarenga & Yangang Pan & ByoungCheol Lee & Xiaolu Cheng & Eva Fortea & Simon Scheuring & Alessio Accardi, 2022. "TMEM16 scramblases thin the membrane to enable lipid scrambling," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
- Andy K. M. Lam & Sonja Rutz & Raimund Dutzler, 2022. "Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
- Mattia Malvezzi & Madhavan Chalat & Radmila Janjusevic & Alessandra Picollo & Hiroyuki Terashima & Anant K. Menon & Alessio Accardi, 2013. "Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel," Nature Communications, Nature, vol. 4(1), pages 1-9, December.
- Andy K. M. Lam & Jan Rheinberger & Cristina Paulino & Raimund Dutzler, 2021. "Gating the pore of the calcium-activated chloride channel TMEM16A," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
- Simon R. Bushell & Ashley C. W. Pike & Maria E. Falzone & Nils J. G. Rorsman & Chau M. Ta & Robin A. Corey & Thomas D. Newport & John C. Christianson & Lara F. Scofano & Chitra A. Shintre & Annamaria , 2019. "The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
- Andy K. M. Lam & Raimund Dutzler, 2021. "Mechanism of pore opening in the calcium-activated chloride channel TMEM16A," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
- George Khelashvili & Maria E. Falzone & Xiaolu Cheng & Byoung-Cheol Lee & Alessio Accardi & Harel Weinstein, 2019. "Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
Citations
Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
Cited by:
- Yuanyue Shan & Mengmeng Zhang & Meiyu Chen & Xinyi Guo & Ying Li & Mingfeng Zhang & Duanqing Pei, 2024. "Activation mechanisms of dimeric mechanosensitive OSCA/TMEM63 channels," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
- Imre Gonda & Simona Sorrentino & Laura Galazzo & Nicolas P. Lichti & Fabian M. Arnold & Ahmad R. Mehdipour & Enrica Bordignon & Markus A. Seeger, 2025. "The mycobacterial ABC transporter IrtAB employs a membrane-facing crevice for siderophore-mediated iron uptake," Nature Communications, Nature, vol. 16(1), pages 1-17, December.
- Shengjie Feng & Cristina Puchades & Juyeon Ko & Hao Wu & Yifei Chen & Eric E. Figueroa & Shuo Gu & Tina W. Han & Brandon Ho & Tong Cheng & Junrui Li & Brian Shoichet & Yuh Nung Jan & Yifan Cheng & Lil, 2023. "Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
- Zhongjie Ye & Nicola Galvanetto & Leonardo Puppulin & Simone Pifferi & Holger Flechsig & Melanie Arndt & Cesar Adolfo Sánchez Triviño & Michael Palma & Shifeng Guo & Horst Vogel & Anna Menini & Clemen, 2024. "Structural heterogeneity of the ion and lipid channel TMEM16F," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
Most related items
These are the items that most often cite the same works as this one and are cited by the same works as this one.- Zhongjie Ye & Nicola Galvanetto & Leonardo Puppulin & Simone Pifferi & Holger Flechsig & Melanie Arndt & Cesar Adolfo Sánchez Triviño & Michael Palma & Shifeng Guo & Horst Vogel & Anna Menini & Clemen, 2024. "Structural heterogeneity of the ion and lipid channel TMEM16F," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
- Andy K. M. Lam & Sonja Rutz & Raimund Dutzler, 2022. "Inhibition mechanism of the chloride channel TMEM16A by the pore blocker 1PBC," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
- Maria E. Falzone & Zhang Feng & Omar E. Alvarenga & Yangang Pan & ByoungCheol Lee & Xiaolu Cheng & Eva Fortea & Simon Scheuring & Alessio Accardi, 2022. "TMEM16 scramblases thin the membrane to enable lipid scrambling," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
- Shengjie Feng & Cristina Puchades & Juyeon Ko & Hao Wu & Yifei Chen & Eric E. Figueroa & Shuo Gu & Tina W. Han & Brandon Ho & Tong Cheng & Junrui Li & Brian Shoichet & Yuh Nung Jan & Yifan Cheng & Lil, 2023. "Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
- Panpan Zhang & Masahiro Maruoka & Ryo Suzuki & Hikaru Katani & Yu Dou & Daniel M. Packwood & Hidetaka Kosako & Motomu Tanaka & Jun Suzuki, 2023. "Extracellular calcium functions as a molecular glue for transmembrane helices to activate the scramblase Xkr4," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
- Wenjuan Zou & Yuedan Fan & Jia Liu & Hankui Cheng & Huitao Hong & Umar Al-Sheikh & Shitian Li & Linhui Zhu & Rong Li & Longyuan He & Yi-Quan Tang & Guohua Zhao & Yongming Zhang & Feng Wang & Renya Zha, 2025. "Anoctamin-1 is a core component of a mechanosensory anion channel complex in C. elegans," Nature Communications, Nature, vol. 16(1), pages 1-19, December.
- Mingfeng Zhang & Yuanyue Shan & Charles D. Cox & Duanqing Pei, 2023. "A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
- Susan A. Leonhardt & Michael D. Purdy & Jonathan R. Grover & Ziwei Yang & Sandra Poulos & William E. McIntire & Elizabeth A. Tatham & Satchal K. Erramilli & Kamil Nosol & Kin Kui Lai & Shilei Ding & M, 2023. "Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
- Weijia Sun & Shuai Guo & Yuheng Li & JianWei Li & Caizhi Liu & Yafei Chen & Xuzhao Wang & Yingjun Tan & Hua Tian & Cheng Wang & Ruikai Du & Guohui Zhong & Sai Shi & Biao Ma & Chang Qu & Jingxuan Fu & , 2022. "Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
- Han Niu & Masahiro Maruoka & Yuki Noguchi & Hidetaka Kosako & Jun Suzuki, 2024. "Phospholipid scrambling induced by an ion channel/metabolite transporter complex," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
- Xinyu Zhang & Tianfang Zhao & Jiansheng Chen & Yuan Shen & Xueming Li, 2022. "EPicker is an exemplar-based continual learning approach for knowledge accumulation in cryoEM particle picking," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
- Samuel Hume & Claudia P. Grou & Pauline Lascaux & Vincenzo D’Angiolella & Arnaud J. Legrand & Kristijan Ramadan & Grigory L. Dianov, 2021. "The NUCKS1-SKP2-p21/p27 axis controls S phase entry," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
- Simon Wiedemann & Reinhard Heckel, 2024. "A deep learning method for simultaneous denoising and missing wedge reconstruction in cryogenic electron tomography," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
- Luka Bacic & Guillaume Gaullier & Jugal Mohapatra & Guanzhong Mao & Klaus Brackmann & Mikhail Panfilov & Glen Liszczak & Anton Sabantsev & Sebastian Deindl, 2024. "Asymmetric nucleosome PARylation at DNA breaks mediates directional nucleosome sliding by ALC1," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
- Yaejin Yun & Hyeongseop Jeong & Thibaut Laboute & Kirill A. Martemyanov & Hyung Ho Lee, 2024. "Cryo-EM structure of human class C orphan GPCR GPR179 involved in visual processing," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
- Leishu Lin & Jiayuan Dong & Shun Xu & Jinman Xiao & Cong Yu & Fengfeng Niu & Zhiyi Wei, 2024. "Autoinhibition and relief mechanisms for MICAL monooxygenases in F-actin disassembly," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
- Sriram Aiyer & Philip R. Baldwin & Shi Min Tan & Zelin Shan & Juntaek Oh & Atousa Mehrani & Marianne E. Bowman & Gordon Louie & Dario Oliveira Passos & Selena Đorđević-Marquardt & Mario Mietzsch & Jos, 2024. "Overcoming resolution attenuation during tilted cryo-EM data collection," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
- Shana Bergman & Rosemary J. Cater & Ambrose Plante & Filippo Mancia & George Khelashvili, 2023. "Substrate binding-induced conformational transitions in the omega-3 fatty acid transporter MFSD2A," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
- Benjamin C. Creekmore & Kathryn Kixmoeller & Ben E. Black & Edward B. Lee & Yi-Wei Chang, 2024. "Ultrastructure of human brain tissue vitrified from autopsy revealed by cryo-ET with cryo-plasma FIB milling," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
- Michael Kugler & Felix J. Metzner & Gregor Witte & Karl-Peter Hopfner & Katja Lammens, 2024. "Phosphorylation-mediated conformational change regulates human SLFN11," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34497-x. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through the various RePEc services.