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Advances in epigenetics link genetics to the environment and disease

Author

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  • Giacomo Cavalli

    (CNRS and University of Montpellier)

  • Edith Heard

    (European Molecular Biology Laboratory (EMBL)
    Collège de France)

Abstract

Epigenetic research has accelerated rapidly in the twenty-first century, generating justified excitement and hope, but also a degree of hype. Here we review how the field has evolved over the last few decades and reflect on some of the recent advances that are changing our understanding of biology. We discuss the interplay between epigenetics and DNA sequence variation as well as the implications of epigenetics for cellular memory and plasticity. We consider the effects of the environment and both intergenerational and transgenerational epigenetic inheritance on biology, disease and evolution. Finally, we present some new frontiers in epigenetics with implications for human health.

Suggested Citation

  • Giacomo Cavalli & Edith Heard, 2019. "Advances in epigenetics link genetics to the environment and disease," Nature, Nature, vol. 571(7766), pages 489-499, July.
    • Handle: RePEc:nat:nature:v:571:y:2019:i:7766:d:10.1038_s41586-019-1411-0
    DOI: 10.1038/s41586-019-1411-0
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    10. van Dijk, Ingrid K. & Nilsson, Therese & Quaranta, Luciana, 2024. "Disease exposure in infancy affects women's reproductive outcomes and offspring health in southern Sweden 1905–2000," Social Science & Medicine, Elsevier, vol. 347(C).
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    16. Xiaoyan Wei & Angelos Rigopoulos & Matthias Lienhard & Sophie Pöhle-Kronawitter & Georgios Kotsaris & Julia Franke & Nikolaus Berndt & Joy Orezimena Mejedo & Hao Wu & Stefan Börno & Bernd Timmermann &, 2024. "Neurofibromin 1 controls metabolic balance and Notch-dependent quiescence of murine juvenile myogenic progenitors," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    17. Zhaozhong Zhu & Yijun Li & Robert J. Freishtat & Juan C. Celedón & Janice A. Espinola & Brennan Harmon & Andrea Hahn & Carlos A. Camargo & Liming Liang & Kohei Hasegawa, 2023. "Epigenome-wide association analysis of infant bronchiolitis severity: a multicenter prospective cohort study," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    18. Kimberly Matheson & Ann Seymour & Jyllenna Landry & Katelyn Ventura & Emily Arsenault & Hymie Anisman, 2022. "Canada’s Colonial Genocide of Indigenous Peoples: A Review of the Psychosocial and Neurobiological Processes Linking Trauma and Intergenerational Outcomes," IJERPH, MDPI, vol. 19(11), pages 1-28, May.
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