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Formation of supramolecular channels by reversible unwinding-rewinding of bis(indole) double helix via ion coordination

Author

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  • Debashis Mondal

    (Indian Institute of Science Education and Research Pune)

  • Manzoor Ahmad

    (Indian Institute of Science Education and Research Pune)

  • Bijoy Dey

    (Tata Institute of Fundamental Research)

  • Abhishek Mondal

    (Indian Institute of Science Education and Research Pune)

  • Pinaki Talukdar

    (Indian Institute of Science Education and Research Pune)

Abstract

Stimulus-responsive reversible transformation between two structural conformers is an essential process in many biological systems. An example of such a process is the conversion of amyloid-β peptide into β-sheet-rich oligomers, which leads to the accumulation of insoluble amyloid in the brain, in Alzheimer’s disease. To reverse this unique structural shift and prevent amyloid accumulation, β-sheet breakers are used. Herein, we report a series of bis(indole)-based biofunctional molecules, which form a stable double helix structure in the solid and solution state. In presence of chloride anion, the double helical structure unwinds to form an anion-coordinated supramolecular polymeric channel, which in turn rewinds upon the addition of Ag+ salts. Moreover, the formation of the anion-induced supramolecular ion channel results in efficient ion transport across lipid bilayer membranes with excellent chloride selectivity. This work demonstrates anion-cation-assisted stimulus-responsive unwinding and rewinding of artificial double-helix systems, paving way for smart materials with better biomedical applications.

Suggested Citation

  • Debashis Mondal & Manzoor Ahmad & Bijoy Dey & Abhishek Mondal & Pinaki Talukdar, 2022. "Formation of supramolecular channels by reversible unwinding-rewinding of bis(indole) double helix via ion coordination," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34159-y
    DOI: 10.1038/s41467-022-34159-y
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    References listed on IDEAS

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    1. Volker Berl & Ivan Huc & Richard G. Khoury & Michael J. Krische & Jean-Marie Lehn, 2000. "Interconversion of single and double helices formed from synthetic molecular strands," Nature, Nature, vol. 407(6805), pages 720-723, October.
    2. Andreas Vargas Jentzsch & Daniel Emery & Jiri Mareda & Susanta K. Nayak & Pierangelo Metrangolo & Giuseppe Resnati & Naomi Sakai & Stefan Matile, 2012. "Transmembrane anion transport mediated by halogen-bond donors," Nature Communications, Nature, vol. 3(1), pages 1-8, January.
    3. Daniel R. Burnham & Hazal B. Kose & Rebecca B. Hoyle & Hasan Yardimci, 2019. "The mechanism of DNA unwinding by the eukaryotic replicative helicase," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    4. Xiaosheng Yan & Kunshan Zou & Jinlian Cao & Xiaorui Li & Zhixing Zhao & Zhao Li & Anan Wu & Wanzhen Liang & Yirong Mo & Yunbao Jiang, 2019. "Single-handed supramolecular double helix of homochiral bis(N-amidothiourea) supported by double crossed C−I···S halogen bonds," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
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    Cited by:

    1. Shanshan Hong & Maria Vincenzo & Alberto Tiraferri & Erica Bertozzi & Radosław Górecki & Bambar Davaasuren & Xiang Li & Suzana P. Nunes, 2024. "Precision ion separation via self-assembled channels," Nature Communications, Nature, vol. 15(1), pages 1-9, December.

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