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Central role of Prominin-1 in lipid rafts during liver regeneration

Author

Listed:
  • Myeong-Suk Bahn

    (Korea University)

  • Dong-Min Yu

    (Korea University)

  • Myoungwoo Lee

    (Korea University)

  • Sung-Je Jo

    (Korea University)

  • Ji-Won Lee

    (Korea University)

  • Ho-Chul Kim

    (Korea University)

  • Hyun Lee

    (Korea University)

  • Hong Lim Kim

    (Integrative Research Support Center, College of Medicine, The Catholic University of Korea)

  • Arum Kim

    (Korea University)

  • Jeong-Ho Hong

    (Korea University)

  • Jun Seok Kim

    (Korea University)

  • Seung-Hoi Koo

    (Korea University)

  • Jae-Seon Lee

    (College of Medicine, Inha University)

  • Young-Gyu Ko

    (Korea University)

Abstract

Prominin-1, a lipid raft protein, is required for maintaining cancer stem cell properties in hepatocarcinoma cell lines, but its physiological roles in the liver have not been well studied. Here, we investigate the role of Prominin-1 in lipid rafts during liver regeneration and show that expression of Prominin-1 increases after 2/3 partial hepatectomy or CCl4 injection. Hepatocyte proliferation and liver regeneration are attenuated in liver-specific Prominin-1 knockout mice compared to wild-type mice. Detailed mechanistic studies reveal that Prominin-1 interacts with the interleukin-6 signal transducer glycoprotein 130, confining it to lipid rafts so that STAT3 signaling by IL-6 is effectively activated. The overexpression of the glycosylphosphatidylinsositol-anchored first extracellular domain of Prominin-1, which is the domain that binds to GP130, rescued the proliferation of hepatocytes and liver regeneration in liver-specific Prominin-1 knockout mice. In summary, Prominin-1 is upregulated in hepatocytes during liver regeneration where it recruits GP130 into lipid rafts and activates the IL6-GP130-STAT3 axis, suggesting that Prominin-1 might be a promising target for therapeutic applications in liver transplantation.

Suggested Citation

  • Myeong-Suk Bahn & Dong-Min Yu & Myoungwoo Lee & Sung-Je Jo & Ji-Won Lee & Ho-Chul Kim & Hyun Lee & Hong Lim Kim & Arum Kim & Jeong-Ho Hong & Jun Seok Kim & Seung-Hoi Koo & Jae-Seon Lee & Young-Gyu Ko, 2022. "Central role of Prominin-1 in lipid rafts during liver regeneration," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33969-4
    DOI: 10.1038/s41467-022-33969-4
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    References listed on IDEAS

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    1. Jae-Sung Yi & Jun Sub Park & Young-Mi Ham & Nga Nguyen & Na-Rae Lee & Jin Hong & Bong-Woo Kim & Hyun Lee & Chang-Seok Lee & Byung-Cheon Jeong & Hyun Kyu Song & Hana Cho & Yoon Ki Kim & Jae-Seon Lee & , 2013. "MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling," Nature Communications, Nature, vol. 4(1), pages 1-12, December.
    2. Shideng Bao & Qiulian Wu & Roger E. McLendon & Yueling Hao & Qing Shi & Anita B. Hjelmeland & Mark W. Dewhirst & Darell D. Bigner & Jeremy N. Rich, 2006. "Glioma stem cells promote radioresistance by preferential activation of the DNA damage response," Nature, Nature, vol. 444(7120), pages 756-760, December.
    3. Wenjuan Pu & Hui Zhang & Xiuzhen Huang & Xueying Tian & Lingjuan He & Yue Wang & Libo Zhang & Qiaozhen Liu & Yan Li & Yi Li & Huan Zhao & Kuo Liu & Jie Lu & Yingqun Zhou & Pengyu Huang & Yu Nie & Yan , 2016. "Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration," Nature Communications, Nature, vol. 7(1), pages 1-15, December.
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