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Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota

Author

Listed:
  • Lucas Moitinho-Silva

    (Kiel University
    University Hospital Schleswig-Holstein)

  • Frauke Degenhardt

    (Kiel University)

  • Elke Rodriguez

    (University Hospital Schleswig-Holstein)

  • Hila Emmert

    (University Hospital Schleswig-Holstein)

  • Simonas Juzenas

    (Kiel University
    Vilnius University)

  • Lena Möbus

    (University Hospital Schleswig-Holstein)

  • Florian Uellendahl-Werth

    (Kiel University)

  • Nicole Sander

    (University Hospital Schleswig-Holstein)

  • Hansjörg Baurecht

    (University of Regensburg)

  • Lukas Tittmann

    (Kiel University)

  • Wolfgang Lieb

    (Kiel University)

  • Christian Gieger

    (Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health)

  • Annette Peters

    (Institute of Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health)

  • David Ellinghaus

    (Kiel University)

  • Corinna Bang

    (Kiel University)

  • Andre Franke

    (Kiel University)

  • Stephan Weidinger

    (University Hospital Schleswig-Holstein)

  • Malte Christoph Rühlemann

    (Kiel University)

Abstract

Despite the increasing knowledge about factors shaping the human microbiome, the host genetic factors that modulate the skin-microbiome interactions are still largely understudied. This contrasts with recent efforts to characterize host genes that influence the gut microbiota. Here, we investigated the effect of genetics on skin microbiota across three different skin microenvironments through meta-analyses of genome-wide association studies (GWAS) of two population-based German cohorts. We identified 23 genome-wide significant loci harboring 30 candidate genes involved in innate immune signaling, environmental sensing, cell differentiation, proliferation and fibroblast activity. However, no locus passed the strict threshold for study-wide significance (P

Suggested Citation

  • Lucas Moitinho-Silva & Frauke Degenhardt & Elke Rodriguez & Hila Emmert & Simonas Juzenas & Lena Möbus & Florian Uellendahl-Werth & Nicole Sander & Hansjörg Baurecht & Lukas Tittmann & Wolfgang Lieb &, 2022. "Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33906-5
    DOI: 10.1038/s41467-022-33906-5
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    References listed on IDEAS

    as
    1. Stock, James H & Wright, Jonathan H & Yogo, Motohiro, 2002. "A Survey of Weak Instruments and Weak Identification in Generalized Method of Moments," Journal of Business & Economic Statistics, American Statistical Association, vol. 20(4), pages 518-529, October.
    2. Julia Oh & Allyson L. Byrd & Clay Deming & Sean Conlan & Heidi H. Kong & Julia A. Segre, 2014. "Biogeography and individuality shape function in the human skin metagenome," Nature, Nature, vol. 514(7520), pages 59-64, October.
    3. Jethro S. Johnson & Daniel J. Spakowicz & Bo-Young Hong & Lauren M. Petersen & Patrick Demkowicz & Lei Chen & Shana R. Leopold & Blake M. Hanson & Hanako O. Agresta & Mark Gerstein & Erica Sodergren &, 2019. "Evaluation of 16S rRNA gene sequencing for species and strain-level microbiome analysis," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
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