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Variation in the fruit development gene POINTED TIP regulates protuberance of tomato fruit tip

Author

Listed:
  • Jianwen Song

    (Huazhong Agricultural University)

  • Lele Shang

    (Huazhong Agricultural University)

  • Changxing Li

    (Huazhong Agricultural University)

  • Wenqian Wang

    (Huazhong Agricultural University)

  • Xin Wang

    (Huazhong Agricultural University
    Hubei Hongshan Laboratory)

  • Chunli Zhang

    (Huazhong Agricultural University)

  • Guo Ai

    (Huazhong Agricultural University)

  • Jie Ye

    (Huazhong Agricultural University)

  • Changxian Yang

    (Huazhong Agricultural University)

  • Hanxia Li

    (Huazhong Agricultural University)

  • Zonglie Hong

    (University of Idaho)

  • Robert M. Larkin

    (Huazhong Agricultural University)

  • Zhibiao Ye

    (Huazhong Agricultural University)

  • Junhong Zhang

    (Huazhong Agricultural University
    Hubei Hongshan Laboratory)

Abstract

The domestication of tomato has led to striking variations in fruit morphology. Here, we show a genome-wide association study (GWAS) to understand the development of the fruit tip and describe a POINTED TIP (PT) gene that encodes a C2H2-type zinc finger transcription factor. A single nucleotide polymorphism is found to change a histidine (H) to an arginine (R) in the C2H2 domain of PT and the two alleles are referred to as PTH and PTR. Knocking out PTH leads to development of pointed tip fruit. PTH functions to suppress pointed tip formation by downregulating the transcription of FRUTFULL 2 (FUL2), which alters the auxin transport. Our evolutionary analysis and previous studies by others suggest that the PTR allele likely hitch-hiked along with other selected loci during the domestication process. This study uncovers variation in PT and molecular mechanism underlying fruit tip development in tomato.

Suggested Citation

  • Jianwen Song & Lele Shang & Changxing Li & Wenqian Wang & Xin Wang & Chunli Zhang & Guo Ai & Jie Ye & Changxian Yang & Hanxia Li & Zonglie Hong & Robert M. Larkin & Zhibiao Ye & Junhong Zhang, 2022. "Variation in the fruit development gene POINTED TIP regulates protuberance of tomato fruit tip," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33648-4
    DOI: 10.1038/s41467-022-33648-4
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    References listed on IDEAS

    as
    1. Shan Wu & Biyao Zhang & Neda Keyhaninejad & Gustavo R. Rodríguez & Hyun Jung Kim & Manohar Chakrabarti & Eudald Illa-Berenguer & Nathan K. Taitano & M. J Gonzalo & Aurora Díaz & Yupeng Pan & Courtney , 2018. "A common genetic mechanism underlies morphological diversity in fruits and other plant organs," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
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    Cited by:

    1. Jinhua Li & Guo Ai & Yaling Wang & Yin Ding & Xiaomeng Hu & Yan Liang & Qingxia Yan & Ke Wu & Rong Huang & Chunrui Chen & Bo Ouyang & Xingguo Zhang & Yu Pan & Lang Wu & Zonglie Hong & Junhong Zhang, 2024. "A truncated B-box zinc finger transcription factor confers drought sensitivity in modern cultivated tomatoes," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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