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A truncated B-box zinc finger transcription factor confers drought sensitivity in modern cultivated tomatoes

Author

Listed:
  • Jinhua Li

    (Southwest University)

  • Guo Ai

    (Huazhong Agricultural University)

  • Yaling Wang

    (Southwest University)

  • Yin Ding

    (Southwest University)

  • Xiaomeng Hu

    (Southwest University)

  • Yan Liang

    (Southwest University)

  • Qingxia Yan

    (Southwest University)

  • Ke Wu

    (Southwest University)

  • Rong Huang

    (Huazhong Agricultural University)

  • Chunrui Chen

    (Southwest University)

  • Bo Ouyang

    (Huazhong Agricultural University)

  • Xingguo Zhang

    (Southwest University)

  • Yu Pan

    (Southwest University)

  • Lang Wu

    (Southwest University)

  • Zonglie Hong

    (University of Idaho)

  • Junhong Zhang

    (Huazhong Agricultural University)

Abstract

Enhancing drought tolerance in crops and understanding the underlying mechanisms have been subject of intense research. The precise function and molecular mechanisms of B-box zinc finger proteins (BBX) remain elusive. Here, we report a natural allele of BBX18 (BBX18TT) that encodes a C-terminal truncated protein. While most wild tomato germplasms contain the BBX18CC allele and show more drought tolerant, modern cultivated tomatoes mostly carry BBX18TT allele and are more drought sensitive. Knockout of BBX18 leads to improved drought tolerance in transgenic plants of cultivated tomato. Ascorbate peroxidase 1 (APX1) is identified as a BBX18-interacting protein that acts as a positive regulator of drought resistance in tomato. Chromatin immunoprecipitation sequencing analyses reveal that BBX18 binds to a unique cis-acting element of the APX1 promoter and represses its gene expression. This study provides insights into the molecular mechanism underlying drought resistance mediated by the BBX18-APX1 module in plants.

Suggested Citation

  • Jinhua Li & Guo Ai & Yaling Wang & Yin Ding & Xiaomeng Hu & Yan Liang & Qingxia Yan & Ke Wu & Rong Huang & Chunrui Chen & Bo Ouyang & Xingguo Zhang & Yu Pan & Lang Wu & Zonglie Hong & Junhong Zhang, 2024. "A truncated B-box zinc finger transcription factor confers drought sensitivity in modern cultivated tomatoes," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51699-7
    DOI: 10.1038/s41467-024-51699-7
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    References listed on IDEAS

    as
    1. Jianwen Song & Lele Shang & Changxing Li & Wenqian Wang & Xin Wang & Chunli Zhang & Guo Ai & Jie Ye & Changxian Yang & Hanxia Li & Zonglie Hong & Robert M. Larkin & Zhibiao Ye & Junhong Zhang, 2022. "Variation in the fruit development gene POINTED TIP regulates protuberance of tomato fruit tip," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
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