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Bidirectional lysosome transport: a balancing act between ARL8 effectors

Author

Listed:
  • Agnieszka A. Kendrick

    (University of California, San Diego)

  • Jenna R. Christensen

    (University of California, San Diego)

Abstract

Most organelles move bidirectionally on microtubule tracks, yet how this opposing movement is regulated by kinesin and dynein remains unclear. Recent work found that ARL8, a known anterograde adaptor linking the lysosome to kinesin, also links lysosomes to the retrograde motor dynein, providing key insight into bidirectional organelle movement in cells.

Suggested Citation

  • Agnieszka A. Kendrick & Jenna R. Christensen, 2022. "Bidirectional lysosome transport: a balancing act between ARL8 effectors," Nature Communications, Nature, vol. 13(1), pages 1-3, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32965-y
    DOI: 10.1038/s41467-022-32965-y
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    References listed on IDEAS

    as
    1. Tal Keren-Kaplan & Amra Sarić & Saikat Ghosh & Chad D. Williamson & Rui Jia & Yan Li & Juan S. Bonifacino, 2022. "RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    2. Gaurav Kumar & Prateek Chawla & Neha Dhiman & Sanya Chadha & Sheetal Sharma & Kanupriya Sethi & Mahak Sharma & Amit Tuli, 2022. "RUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    Full references (including those not matched with items on IDEAS)

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