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Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology

Author

Listed:
  • Yixin Wu

    (Northwestern University
    Northwestern University
    Northwestern University)

  • Mingzheng Wu

    (Northwestern University)

  • Abraham Vázquez-Guardado

    (Northwestern University
    Northwestern University)

  • Joohee Kim

    (Northwestern University
    Northwestern University
    Korea Institute of Science and Technology)

  • Xin Zhang

    (Northwestern University)

  • Raudel Avila

    (Northwestern University)

  • Jin-Tae Kim

    (Northwestern University
    Northwestern University)

  • Yujun Deng

    (Northwestern University
    Shanghai Jiao Tong University)

  • Yongjoon Yu

    (Neurolux Inc)

  • Sarah Melzer

    (Harvard Medical School)

  • Yun Bai

    (Northwestern University
    Northwestern University
    Northwestern University)

  • Hyoseo Yoon

    (Northwestern University)

  • Lingzi Meng

    (Northwestern University
    Northwestern University
    Northwestern University)

  • Yi Zhang

    (University of Connecticut
    University of Connecticut)

  • Hexia Guo

    (Northwestern University
    Northwestern University
    Northwestern University)

  • Liu Hong

    (University of Illinois)

  • Evangelos E. Kanatzidis

    (Northwestern University
    Northwestern University
    Northwestern University)

  • Chad R. Haney

    (Northwestern University)

  • Emily A. Waters

    (Northwestern University)

  • Anthony R. Banks

    (Northwestern University
    Neurolux Inc)

  • Ziying Hu

    (Northwestern University
    Northwestern University)

  • Ferrona Lie

    (Neurolux Inc)

  • Leonardo P. Chamorro

    (University of Illinois)

  • Bernardo L. Sabatini

    (Harvard Medical School)

  • Yonggang Huang

    (Northwestern University
    Northwestern University
    Northwestern University)

  • Yevgenia Kozorovitskiy

    (Northwestern University
    Northwestern University)

  • John A. Rogers

    (Northwestern University
    Northwestern University
    Northwestern University
    Neurolux Inc)

Abstract

In vivo optogenetics and photopharmacology are two techniques for controlling neuronal activity that have immense potential in neuroscience research. Their applications in tether-free groups of animals have been limited in part due to tools availability. Here, we present a wireless, battery-free, programable multilateral optofluidic platform with user-selected modalities for optogenetics, pharmacology and photopharmacology. This system features mechanically compliant microfluidic and electronic interconnects, capabilities for dynamic control over the rates of drug delivery and real-time programmability, simultaneously for up to 256 separate devices in a single cage environment. Our behavioral experiments demonstrate control of motor behaviors in grouped mice through in vivo optogenetics with co-located gene delivery and controlled photolysis of caged glutamate. These optofluidic systems may expand the scope of wireless techniques to study neural processing in animal models.

Suggested Citation

  • Yixin Wu & Mingzheng Wu & Abraham Vázquez-Guardado & Joohee Kim & Xin Zhang & Raudel Avila & Jin-Tae Kim & Yujun Deng & Yongjoon Yu & Sarah Melzer & Yun Bai & Hyoseo Yoon & Lingzi Meng & Yi Zhang & He, 2022. "Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32947-0
    DOI: 10.1038/s41467-022-32947-0
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    References listed on IDEAS

    as
    1. Hyung-Bae Kwon & Bernardo L. Sabatini, 2011. "Glutamate induces de novo growth of functional spines in developing cortex," Nature, Nature, vol. 474(7349), pages 100-104, June.
    2. Yevgenia Kozorovitskiy & Arpiar Saunders & Caroline A. Johnson & Bradford B. Lowell & Bernardo L. Sabatini, 2012. "Recurrent network activity drives striatal synaptogenesis," Nature, Nature, vol. 485(7400), pages 646-650, May.
    3. Yevgenia Kozorovitskiy & Arpiar Saunders & Caroline A. Johnson & Bradford B. Lowell & Bernardo L. Sabatini, 2012. "Correction: Corrigendum: Recurrent network activity drives striatal synaptogenesis," Nature, Nature, vol. 489(7415), pages 326-326, September.
    Full references (including those not matched with items on IDEAS)

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