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Noninvasive imaging of the tumor immune microenvironment correlates with response to immunotherapy in gastric cancer

Author

Listed:
  • Weicai Huang

    (Southern Medical University
    Southern Medical University)

  • Yuming Jiang

    (Southern Medical University
    Southern Medical University)

  • Wenjun Xiong

    (the Second Affiliated Hospital of Guangzhou University of Chinese Medicine)

  • Zepang Sun

    (Southern Medical University
    Southern Medical University)

  • Chuanli Chen

    (Southern Medical University)

  • Qingyu Yuan

    (Southern Medical University)

  • Kangneng Zhou

    (University of Science and Technology Beijing)

  • Zhen Han

    (Southern Medical University
    Southern Medical University)

  • Hao Feng

    (Southern Medical University
    Southern Medical University)

  • Hao Chen

    (Southern Medical University
    Southern Medical University)

  • Xiaokun Liang

    (Chinese Academy of Sciences)

  • Shitong Yu

    (Southern Medical University
    Southern Medical University)

  • Yanfeng Hu

    (Southern Medical University
    Southern Medical University)

  • Jiang Yu

    (Southern Medical University
    Southern Medical University)

  • Yan Chen

    (Guangzhou University of Chinese Medicine)

  • Liying Zhao

    (Southern Medical University
    Southern Medical University)

  • Hao Liu

    (Southern Medical University
    Southern Medical University)

  • Zhiwei Zhou

    (Sun Yat-sen University Cancer Center
    Collaborative Innovation Center for Cancer Medicine)

  • Wei Wang

    (the Second Affiliated Hospital of Guangzhou University of Chinese Medicine)

  • Wei Wang

    (Sun Yat-sen University Cancer Center
    Collaborative Innovation Center for Cancer Medicine)

  • Yikai Xu

    (Southern Medical University)

  • Guoxin Li

    (Southern Medical University
    Southern Medical University)

Abstract

The tumor immune microenvironment (TIME) is associated with tumor prognosis and immunotherapy response. Here we develop and validate a CT-based radiomics score (RS) using 2272 gastric cancer (GC) patients to investigate the relationship between the radiomics imaging biomarker and the neutrophil-to-lymphocyte ratio (NLR) in the TIME, including its correlation with prognosis and immunotherapy response in advanced GC. The RS achieves an AUC of 0.795–0.861 in predicting the NLR in the TIME. Notably, the radiomics imaging biomarker is indistinguishable from the IHC-derived NLR status in predicting DFS and OS in each cohort (HR range: 1.694–3.394, P

Suggested Citation

  • Weicai Huang & Yuming Jiang & Wenjun Xiong & Zepang Sun & Chuanli Chen & Qingyu Yuan & Kangneng Zhou & Zhen Han & Hao Feng & Hao Chen & Xiaokun Liang & Shitong Yu & Yanfeng Hu & Jiang Yu & Yan Chen & , 2022. "Noninvasive imaging of the tumor immune microenvironment correlates with response to immunotherapy in gastric cancer," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32816-w
    DOI: 10.1038/s41467-022-32816-w
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    References listed on IDEAS

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    2. Daniel S. Chen & Ira Mellman, 2017. "Elements of cancer immunity and the cancer–immune set point," Nature, Nature, vol. 541(7637), pages 321-330, January.
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