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An interplay between cellular growth and atypical fusion defines morphogenesis of a modular glial niche in Drosophila

Author

Listed:
  • Maria Alexandra Rujano

    (Institut Pasteur, CNRS UMR3738)

  • David Briand

    (Institut Pasteur, CNRS UMR3738)

  • Bojana Ðelić

    (Institut Pasteur, CNRS UMR3738
    Cell Division and Neurogenesis, Ecole Normale Supérieure, CNRS, Inserm, PSL Université Paris)

  • Julie Marc

    (Institut Pasteur, CNRS UMR3738)

  • Pauline Spéder

    (Institut Pasteur, CNRS UMR3738)

Abstract

Neural stem cells (NSCs) live in an intricate cellular microenvironment supporting their activity, the niche. Whilst shape and function are inseparable, the morphogenetic aspects of niche development are poorly understood. Here, we use the formation of a glial niche to investigate acquisition of architectural complexity. Cortex glia (CG) in Drosophila regulate neurogenesis and build a reticular structure around NSCs. We first show that individual CG cells grow tremendously to ensheath several NSC lineages, employing elaborate proliferative mechanisms which convert these cells into syncytia rich in cytoplasmic bridges. CG syncytia further undergo homotypic cell–cell fusion, using defined cell surface receptors and actin regulators. Cellular exchange is however dynamic in space and time. This atypical cell fusion remodels cellular borders, restructuring the CG syncytia. Ultimately, combined growth and fusion builds the multi-level architecture of the niche, and creates a modular, spatial partition of the NSC population. Our findings provide insights into how a niche forms and organises while developing intimate contacts with a stem cell population.

Suggested Citation

  • Maria Alexandra Rujano & David Briand & Bojana Ðelić & Julie Marc & Pauline Spéder, 2022. "An interplay between cellular growth and atypical fusion defines morphogenesis of a modular glial niche in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-25, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32685-3
    DOI: 10.1038/s41467-022-32685-3
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    References listed on IDEAS

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    1. Billel Benmimoun & Florentia Papastefanaki & Bruno Périchon & Katerina Segklia & Nicolas Roby & Vivi Miriagou & Christine Schmitt & Shaynoor Dramsi & Rebecca Matsas & Pauline Spéder, 2020. "An original infection model identifies host lipoprotein import as a route for blood-brain barrier crossing," Nature Communications, Nature, vol. 11(1), pages 1-18, December.
    2. Delphine Gogendeau & Katarzyna Siudeja & Davide Gambarotto & Carole Pennetier & Allison J. Bardin & Renata Basto, 2015. "Aneuploidy causes premature differentiation of neural and intestinal stem cells," Nature Communications, Nature, vol. 6(1), pages 1-15, December.
    3. Rita Sousa-Nunes & Lih Ling Yee & Alex P. Gould, 2011. "Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila," Nature, Nature, vol. 471(7339), pages 508-512, March.
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