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Aneuploidy causes premature differentiation of neural and intestinal stem cells

Author

Listed:
  • Delphine Gogendeau

    (Institut Curie, PSL Research University, CNRS UMR144)

  • Katarzyna Siudeja

    (Institut Curie, CNRS UMR3215, INSERM U934)

  • Davide Gambarotto

    (Institut Curie, PSL Research University, CNRS UMR144)

  • Carole Pennetier

    (Institut Curie, PSL Research University, CNRS UMR144)

  • Allison J. Bardin

    (Institut Curie, CNRS UMR3215, INSERM U934)

  • Renata Basto

    (Institut Curie, PSL Research University, CNRS UMR144)

Abstract

Aneuploidy is associated with a variety of diseases such as cancer and microcephaly. Although many studies have addressed the consequences of a non-euploid genome in cells, little is known about their overall consequences in tissue and organism development. Here we use two different mutant conditions to address the consequences of aneuploidy during tissue development and homeostasis in Drosophila. We show that aneuploidy causes brain size reduction due to a decrease in the number of proliferative neural stem cells (NSCs), but not through apoptosis. Instead, aneuploid NSCs present an extended G1 phase, which leads to cell cycle exit and premature differentiation. Moreover, we show that this response to aneuploidy is also present in adult intestinal stem cells but not in the wing disc. Our work highlights a neural and intestine stem cell-specific response to aneuploidy, which prevents their proliferation and expansion.

Suggested Citation

  • Delphine Gogendeau & Katarzyna Siudeja & Davide Gambarotto & Carole Pennetier & Allison J. Bardin & Renata Basto, 2015. "Aneuploidy causes premature differentiation of neural and intestinal stem cells," Nature Communications, Nature, vol. 6(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms9894
    DOI: 10.1038/ncomms9894
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    Cited by:

    1. Maria Alexandra Rujano & David Briand & Bojana Ðelić & Julie Marc & Pauline Spéder, 2022. "An interplay between cellular growth and atypical fusion defines morphogenesis of a modular glial niche in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-25, December.

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