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Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila

Author

Listed:
  • Rita Sousa-Nunes

    (Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill)

  • Lih Ling Yee

    (Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill)

  • Alex P. Gould

    (Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill)

Abstract

Nerve progenitors hungry for action The availability of nutrients prompts quiescent neural stem cells (neuroblasts) in Drosophila larvae to begin to divide. A study of the mechanism linking diet to stem-cell behaviour has identified a relay mechanism regulating this nutritional checkpoint. Specific insulin-like peptides produced within the brain by glia — non-neuronal cells with various physical and biochemical support roles — form a bridge from the amino-acid/TOR-dependent signal derived from the fat body to PI3K/TOR signalling in neuroblasts to induce exit from quiescence.

Suggested Citation

  • Rita Sousa-Nunes & Lih Ling Yee & Alex P. Gould, 2011. "Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila," Nature, Nature, vol. 471(7339), pages 508-512, March.
    • Handle: RePEc:nat:nature:v:471:y:2011:i:7339:d:10.1038_nature09867
    DOI: 10.1038/nature09867
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    Cited by:

    1. Yang Gao & Ye Sing Tan & Jiaen Lin & Liang Yuh Chew & Htet Yamin Aung & Brinda Palliyana & Mahekta R. Gujar & Kun-Yang Lin & Shu Kondo & Hongyan Wang, 2024. "SUMOylation of Warts kinase promotes neural stem cell reactivation," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Tom W. Andrew & Lauren S. Koepke & Yuting Wang & Michael Lopez & Holly Steininger & Danielle Struck & Tatiana Boyko & Thomas H. Ambrosi & Xinming Tong & Yuxi Sun & Gunsagar S. Gulati & Matthew P. Murp, 2022. "Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Maria Alexandra Rujano & David Briand & Bojana Ðelić & Julie Marc & Pauline Spéder, 2022. "An interplay between cellular growth and atypical fusion defines morphogenesis of a modular glial niche in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-25, December.
    4. Junjun Gao & Song Zhang & Pan Deng & Zhigang Wu & Bruno Lemaitre & Zongzhao Zhai & Zheng Guo, 2024. "Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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