IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v471y2011i7339d10.1038_nature09867.html
   My bibliography  Save this article

Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila

Author

Listed:
  • Rita Sousa-Nunes

    (Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill)

  • Lih Ling Yee

    (Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill)

  • Alex P. Gould

    (Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill)

Abstract

Nerve progenitors hungry for action The availability of nutrients prompts quiescent neural stem cells (neuroblasts) in Drosophila larvae to begin to divide. A study of the mechanism linking diet to stem-cell behaviour has identified a relay mechanism regulating this nutritional checkpoint. Specific insulin-like peptides produced within the brain by glia — non-neuronal cells with various physical and biochemical support roles — form a bridge from the amino-acid/TOR-dependent signal derived from the fat body to PI3K/TOR signalling in neuroblasts to induce exit from quiescence.

Suggested Citation

  • Rita Sousa-Nunes & Lih Ling Yee & Alex P. Gould, 2011. "Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila," Nature, Nature, vol. 471(7339), pages 508-512, March.
    • Handle: RePEc:nat:nature:v:471:y:2011:i:7339:d:10.1038_nature09867
    DOI: 10.1038/nature09867
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature09867
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature09867?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Tom W. Andrew & Lauren S. Koepke & Yuting Wang & Michael Lopez & Holly Steininger & Danielle Struck & Tatiana Boyko & Thomas H. Ambrosi & Xinming Tong & Yuxi Sun & Gunsagar S. Gulati & Matthew P. Murp, 2022. "Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Maria Alexandra Rujano & David Briand & Bojana Ðelić & Julie Marc & Pauline Spéder, 2022. "An interplay between cellular growth and atypical fusion defines morphogenesis of a modular glial niche in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-25, December.
    3. Junjun Gao & Song Zhang & Pan Deng & Zhigang Wu & Bruno Lemaitre & Zongzhao Zhai & Zheng Guo, 2024. "Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:471:y:2011:i:7339:d:10.1038_nature09867. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.