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A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes to spatial coding and memory

Author

Listed:
  • Yoav Ben-Simon

    (Institute of Science and Technology Austria (ISTA)
    Vienna Medical University)

  • Karola Kaefer

    (Institute of Science and Technology Austria (ISTA)
    Radboud University)

  • Philipp Velicky

    (Institute of Science and Technology Austria (ISTA))

  • Jozsef Csicsvari

    (Institute of Science and Technology Austria (ISTA))

  • Johann G. Danzl

    (Institute of Science and Technology Austria (ISTA))

  • Peter Jonas

    (Institute of Science and Technology Austria (ISTA))

Abstract

The mammalian hippocampal formation (HF) plays a key role in several higher brain functions, such as spatial coding, learning and memory. Its simple circuit architecture is often viewed as a trisynaptic loop, processing input originating from the superficial layers of the entorhinal cortex (EC) and sending it back to its deeper layers. Here, we show that excitatory neurons in layer 6b of the mouse EC project to all sub-regions comprising the HF and receive input from the CA1, thalamus and claustrum. Furthermore, their output is characterized by unique slow-decaying excitatory postsynaptic currents capable of driving plateau-like potentials in their postsynaptic targets. Optogenetic inhibition of the EC-6b pathway affects spatial coding in CA1 pyramidal neurons, while cell ablation impairs not only acquisition of new spatial memories, but also degradation of previously acquired ones. Our results provide evidence of a functional role for cortical layer 6b neurons in the adult brain.

Suggested Citation

  • Yoav Ben-Simon & Karola Kaefer & Philipp Velicky & Jozsef Csicsvari & Johann G. Danzl & Peter Jonas, 2022. "A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes to spatial coding and memory," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32559-8
    DOI: 10.1038/s41467-022-32559-8
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    References listed on IDEAS

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    1. Trygve E. Bakken & Nikolas L. Jorstad & Qiwen Hu & Blue B. Lake & Wei Tian & Brian E. Kalmbach & Megan Crow & Rebecca D. Hodge & Fenna M. Krienen & Staci A. Sorensen & Jeroen Eggermont & Zizhen Yao & , 2021. "Comparative cellular analysis of motor cortex in human, marmoset and mouse," Nature, Nature, vol. 598(7879), pages 111-119, October.
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    1. Qiming Shao & Ligu Chen & Xiaowan Li & Miao Li & Hui Cui & Xiaoyue Li & Xinran Zhao & Yuying Shi & Qiang Sun & Kaiyue Yan & Guangfu Wang, 2024. "A non-canonical visual cortical-entorhinal pathway contributes to spatial navigation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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