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Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex

Author

Listed:
  • Manfred J. Oswald

    (Heidelberg University)

  • Yechao Han

    (Heidelberg University)

  • Han Li

    (Heidelberg University)

  • Samuel Marashli

    (Heidelberg University)

  • Deniz Nouri Oglo

    (Heidelberg University)

  • Bhavya Ojha

    (Heidelberg University)

  • Paul V. Naser

    (Heidelberg University)

  • Zheng Gan

    (Heidelberg University)

  • Rohini Kuner

    (Heidelberg University)

Abstract

The basal nucleus of Meynert (NBM) subserves critically important functions in attention, arousal and cognition via its profound modulation of neocortical activity and is emerging as a key target in Alzheimer’s and Parkinson’s dementias. Despite the crucial role of neocortical domains in pain perception, however, the NBM has not been studied in models of chronic pain. Here, using in vivo tetrode recordings in behaving mice, we report that beta and gamma oscillatory activity is evoked in the NBM by noxious stimuli and is facilitated at peak inflammatory pain-like behavior. Optogenetic and chemogenetic cell-specific, reversible manipulations of NBM cholinergic-GABAergic neurons reveal their role in endogenous control of nociceptive hypersensitivity, which are manifest via projections to the prelimbic cortex, resulting in layer 5-mediated antinociception. Our data unravel the importance of the NBM in top-down control of neocortical processing of pain-like behavior.

Suggested Citation

  • Manfred J. Oswald & Yechao Han & Han Li & Samuel Marashli & Deniz Nouri Oglo & Bhavya Ojha & Paul V. Naser & Zheng Gan & Rohini Kuner, 2022. "Cholinergic basal forebrain nucleus of Meynert regulates chronic pain-like behavior via modulation of the prelimbic cortex," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32558-9
    DOI: 10.1038/s41467-022-32558-9
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    References listed on IDEAS

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    1. Linette Liqi Tan & Manfred Josef Oswald & Céline Heinl & Oscar Andrés Retana Romero & Sanjeev Kumar Kaushalya & Hannah Monyer & Rohini Kuner, 2019. "Gamma oscillations in somatosensory cortex recruit prefrontal and descending serotonergic pathways in aversion and nociception," Nature Communications, Nature, vol. 10(1), pages 1-17, December.
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    Cited by:

    1. Fan Mei & Chen Zhao & Shangjin Li & Zeping Xue & Yueyang Zhao & Yihua Xu & Rongrong Ye & He You & Peng Yu & Xinyu Han & Gregory V. Carr & Daniel R. Weinberger & Feng Yang & Bai Lu, 2024. "Ngfr+ cholinergic projection from SI/nBM to mPFC selectively regulates temporal order recognition memory," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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