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Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection

Author

Listed:
  • Guillermo Barturen

    (GENYO. Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government)

  • Elena Carnero-Montoro

    (GENYO. Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government)

  • Manuel Martínez-Bueno

    (GENYO. Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government)

  • Silvia Rojo-Rello

    (Hospital Clínico Universitario de Valladolid)

  • Beatriz Sobrino

    (Hospital Regional de Málaga
    IBIMA. Instituto de Investigación Biomédica de Málaga)

  • Óscar Porras-Perales

    (Hospital Regional de Málaga
    IBIMA. Instituto de Investigación Biomédica de Málaga)

  • Clara Alcántara-Domínguez

    (Lorgen G.P., S.L., Business Innovation Center - BIC/CEEL, Technological Area of Health Science)

  • David Bernardo

    (Mucosal Immunology Lab. Unidad de Excelencia Instituto de Biomedicina y Genética Molecular de Valladolid (IBGM, Universidad de Valladolid-CSIC)
    Centro de Investigaciones Biomédicas en Red en Enfermedades Infecciosas (CIBERINFEC))

  • Marta E. Alarcón-Riquelme

    (GENYO. Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government
    Karolinska Institutet)

Abstract

SARS-CoV-2 infection can cause an inflammatory syndrome (COVID-19) leading, in many cases, to bilateral pneumonia, severe dyspnea, and in ~5% of these, death. DNA methylation is known to play an important role in the regulation of the immune processes behind COVID-19 progression, however it has not been studied in depth. In this study, we aim to evaluate the implication of DNA methylation in COVID-19 progression by means of a genome-wide DNA methylation analysis combined with DNA genotyping. The results reveal the existence of epigenomic regulation of functional pathways associated with COVID-19 progression and mediated by genetic loci. We find an environmental trait-related signature that discriminates mild from severe cases and regulates, among other cytokines, IL-6 expression via the transcription factor CEBP. The analyses suggest that an interaction between environmental contribution, genetics, and epigenetics might be playing a role in triggering the cytokine storm described in the most severe cases.

Suggested Citation

  • Guillermo Barturen & Elena Carnero-Montoro & Manuel Martínez-Bueno & Silvia Rojo-Rello & Beatriz Sobrino & Óscar Porras-Perales & Clara Alcántara-Domínguez & David Bernardo & Marta E. Alarcón-Riquelme, 2022. "Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32357-2
    DOI: 10.1038/s41467-022-32357-2
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    References listed on IDEAS

    as
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    Cited by:

    1. Tianyu Zhu & Huige Tong & Zhaozhen Du & Stephan Beck & Andrew E. Teschendorff, 2024. "An improved epigenetic counter to track mitotic age in normal and precancerous tissues," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Zhaozhong Zhu & Yijun Li & Robert J. Freishtat & Juan C. Celedón & Janice A. Espinola & Brennan Harmon & Andrea Hahn & Carlos A. Camargo & Liming Liang & Kohei Hasegawa, 2023. "Epigenome-wide association analysis of infant bronchiolitis severity: a multicenter prospective cohort study," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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