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Precise electrical gating of the single-molecule Mizoroki-Heck reaction

Author

Listed:
  • Lei Zhang

    (Peking University
    Peking University)

  • Chen Yang

    (Peking University)

  • Chenxi Lu

    (University of California)

  • Xingxing Li

    (University of Science and Technology of China)

  • Yilin Guo

    (Peking University)

  • Jianning Zhang

    (Peking University)

  • Jinglong Lin

    (Peking University)

  • Zhizhou Li

    (Peking University)

  • Chuancheng Jia

    (Nankai University)

  • Jinlong Yang

    (University of Science and Technology of China)

  • K. N. Houk

    (University of California)

  • Fanyang Mo

    (Peking University)

  • Xuefeng Guo

    (Peking University
    Nankai University)

Abstract

Precise tuning of chemical reactions with predictable and controllable manners, an ultimate goal chemists desire to achieve, is valuable in the scientific community. This tunability is necessary to understand and regulate chemical transformations at both macroscopic and single-molecule levels to meet demands in potential application scenarios. Herein, we realise accurate tuning of a single-molecule Mizoroki-Heck reaction via applying gate voltages as well as complete deciphering of its detailed intrinsic mechanism by employing an in-situ electrical single-molecule detection, which possesses the capability of single-event tracking. The Mizoroki-Heck reaction can be regulated in different dimensions with a constant catalyst molecule, including the molecular orbital gating of Pd(0) catalyst, the on/off switching of the Mizoroki-Heck reaction, the promotion of its turnover frequency, and the regulation of each elementary reaction within the Mizoroki-Heck catalytic cycle. These results extend the tuning scope of chemical reactions from the macroscopic view to the single-molecule approach, inspiring new insights into designing different strategies or devices to unveil reaction mechanisms and discover novel phenomena.

Suggested Citation

  • Lei Zhang & Chen Yang & Chenxi Lu & Xingxing Li & Yilin Guo & Jianning Zhang & Jinglong Lin & Zhizhou Li & Chuancheng Jia & Jinlong Yang & K. N. Houk & Fanyang Mo & Xuefeng Guo, 2022. "Precise electrical gating of the single-molecule Mizoroki-Heck reaction," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32351-8
    DOI: 10.1038/s41467-022-32351-8
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    References listed on IDEAS

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    Cited by:

    1. Shuzhi Liu & Jianmin Zeng & Zhixin Wu & Han Hu & Ao Xu & Xiaohe Huang & Weilin Chen & Qilai Chen & Zhe Yu & Yinyu Zhao & Rong Wang & Tingting Han & Chao Li & Pingqi Gao & Hyunwoo Kim & Seung Jae Baik , 2023. "An ultrasmall organic synapse for neuromorphic computing," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Cong Zhao & Jiazheng Diao & Zhao Liu & Jie Hao & Suhang He & Shaojia Li & Xingxing Li & Guangwu Li & Qiang Fu & Chuancheng Jia & Xuefeng Guo, 2024. "Electrical monitoring of single-event protonation dynamics at the solid-liquid interface and its regulation by external mechanical forces," Nature Communications, Nature, vol. 15(1), pages 1-9, December.

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