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Post-recovery COVID-19 and incident heart failure in the National COVID Cohort Collaborative (N3C) study

Author

Listed:
  • Husam M. Salah

    (University of Arkansas for Medical Sciences)

  • Marat Fudim

    (Duke University School of Medicine
    Duke University School of Medicine)

  • Shawn T. O’Neil

    (University of Colorado Anschutz Medical Campus)

  • Amin Manna

    (Palantir Technologies)

  • Christopher G. Chute

    (Johns Hopkins University)

  • Melissa C. Caughey

    (University of North Carolina and North Carolina State University)

Abstract

Cardiac involvement has been noted in COVID-19 infection. However, the relationship between post-recovery COVID-19 and development of de novo heart failure has not been investigated in a large, nationally representative population. We examined post-recovery outcomes of 587,330 patients hospitalized in the United States (257,075 with COVID-19 and 330,255 without), using data from the National COVID Cohort Collaborative study. Patients hospitalized with COVID-19 were older (51 vs. 46 years), more often male (49% vs. 42%), and less often White (61% vs. 69%). Over a median follow up of 367 days, 10,979 incident heart failure events occurred. After adjustments, COVID-19 hospitalization was associated with a 45% higher hazard of incident heart failure (hazard ratio = 1.45; 95% confidence interval: 1.39–1.51), with more pronounced associations among patients who were younger (P-interaction = 0.003), White (P-interaction = 0.005), or who had established cardiovascular disease (P-interaction = 0.005). In conclusion, COVID-19 hospitalization is associated with increased risk of incident heart failure.

Suggested Citation

  • Husam M. Salah & Marat Fudim & Shawn T. O’Neil & Amin Manna & Christopher G. Chute & Melissa C. Caughey, 2022. "Post-recovery COVID-19 and incident heart failure in the National COVID Cohort Collaborative (N3C) study," Nature Communications, Nature, vol. 13(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31834-y
    DOI: 10.1038/s41467-022-31834-y
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    References listed on IDEAS

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    1. Michael Marshall, 2020. "The lasting misery of coronavirus long-haulers," Nature, Nature, vol. 585(7825), pages 339-341, September.
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