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Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain

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  • Martin J. Gunthorpe

    (Stevenage Bioscience Catalyst)

Abstract

Kv3 channels enable neurons to fire at very high frequencies (>100 Hz) which is fundamental to brain development and our ability to make sense of the world at large. Cryo-EM and structure-function studies by Chi et al. now uncover Kv3 channel gating mechanisms and support new precision medicine approaches for CNS diseases.

Suggested Citation

  • Martin J. Gunthorpe, 2022. "Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain," Nature Communications, Nature, vol. 13(1), pages 1-4, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31537-4
    DOI: 10.1038/s41467-022-31537-4
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    References listed on IDEAS

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    1. Yoshiaki Kise & Go Kasuya & Hiroyuki H. Okamoto & Daichi Yamanouchi & Kan Kobayashi & Tsukasa Kusakizako & Tomohiro Nishizawa & Koichi Nakajo & Osamu Nureki, 2021. "Structural basis of gating modulation of Kv4 channel complexes," Nature, Nature, vol. 599(7883), pages 158-164, November.
    2. Gamma Chi & Qiansheng Liang & Akshay Sridhar & John B. Cowgill & Kasim Sader & Mazdak Radjainia & Pu Qian & Pablo Castro-Hartmann & Shayla Venkaya & Nanki Kaur Singh & Gavin McKinley & Alejandra Ferna, 2022. "Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Alain J. Labro & Michael F. Priest & Jérôme J. Lacroix & Dirk J. Snyders & Francisco Bezanilla, 2015. "Kv3.1 uses a timely resurgent K+ current to secure action potential repolarization," Nature Communications, Nature, vol. 6(1), pages 1-12, December.
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    Cited by:

    1. Qiansheng Liang & Gamma Chi & Leonardo Cirqueira & Lianteng Zhi & Agostino Marasco & Nadia Pilati & Martin J. Gunthorpe & Giuseppe Alvaro & Charles H. Large & David B. Sauer & Werner Treptow & Manuel , 2024. "The binding and mechanism of a positive allosteric modulator of Kv3 channels," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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