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A structural and functional subdivision in central orbitofrontal cortex

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  • Maya Zhe Wang

    (University of Minnesota
    Center for Magnetic Resonance Research, University of Minnesota)

  • Benjamin Y. Hayden

    (University of Minnesota
    Center for Magnetic Resonance Research, University of Minnesota)

  • Sarah R. Heilbronner

    (University of Minnesota)

Abstract

Economic choice requires many cognitive subprocesses, including stimulus detection, valuation, motor output, and outcome monitoring; many of these subprocesses are associated with the central orbitofrontal cortex (cOFC). Prior work has largely assumed that the cOFC is a single region with a single function. Here, we challenge that unified view with convergent anatomical and physiological results from rhesus macaques. Anatomically, we show that the cOFC can be subdivided according to its much stronger (medial) or weaker (lateral) bidirectional anatomical connectivity with the posterior cingulate cortex (PCC). We call these subregions cOFCm and cOFCl, respectively. These two subregions have notable functional differences. Specifically, cOFCm shows enhanced functional connectivity with PCC, as indicated by both spike-field coherence and mutual information. The cOFCm-PCC circuit, but not the cOFCl-PCC circuit, shows signatures of relaying choice signals from a non-spatial comparison framework to a spatially framed organization and shows a putative bidirectional mutually excitatory pattern.

Suggested Citation

  • Maya Zhe Wang & Benjamin Y. Hayden & Sarah R. Heilbronner, 2022. "A structural and functional subdivision in central orbitofrontal cortex," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31273-9
    DOI: 10.1038/s41467-022-31273-9
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    References listed on IDEAS

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    1. Maya Zhe Wang & Benjamin Y. Hayden, 2017. "Reactivation of associative structure specific outcome responses during prospective evaluation in reward-based choices," Nature Communications, Nature, vol. 8(1), pages 1-13, August.
    2. Valerio Mante & David Sussillo & Krishna V. Shenoy & William T. Newsome, 2013. "Context-dependent computation by recurrent dynamics in prefrontal cortex," Nature, Nature, vol. 503(7474), pages 78-84, November.
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    4. Shiva Farashahi & Christopher H. Donahue & Benjamin Y. Hayden & Daeyeol Lee & Alireza Soltani, 2019. "Flexible combination of reward information across primates," Nature Human Behaviour, Nature, vol. 3(11), pages 1215-1224, November.
    5. Granger, C W J, 1969. "Investigating Causal Relations by Econometric Models and Cross-Spectral Methods," Econometrica, Econometric Society, vol. 37(3), pages 424-438, July.
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    Cited by:

    1. Demetrio Ferro & Tyler Cash-Padgett & Maya Zhe Wang & Benjamin Y. Hayden & Rubén Moreno-Bote, 2024. "Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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