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Terahertz thermal curve analysis for label-free identification of pathogens

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Listed:
  • S. W. Jun

    (Ajou University
    Ajou University)

  • Y. H. Ahn

    (Ajou University
    Ajou University)

Abstract

In this study, we perform a thermal curve analysis with terahertz (THz) metamaterials to develop a label-free identification tool for pathogens such as bacteria and yeasts. The resonant frequency of the metasensor coated with a bacterial layer changes as a function of temperature; this provides a unique fingerprint specific to the individual microbial species without the use of fluorescent dyes and antibodies. Differential thermal curves obtained from the temperature-dependent resonance exhibit the peaks consistent with bacterial phases, such as growth, thermal inactivation, DNA denaturation, and cell wall destruction. In addition, we can distinguish gram-negative bacteria from gram-positive bacteria which show strong peaks in the temperature range of cell wall destruction. Finally, we perform THz melting curve analysis on the mixture of bacterial species in which the pathogenic bacteria are successfully distinguished from each other, which is essential for practical clinical and environmental applications such as in blood culture.

Suggested Citation

  • S. W. Jun & Y. H. Ahn, 2022. "Terahertz thermal curve analysis for label-free identification of pathogens," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31137-2
    DOI: 10.1038/s41467-022-31137-2
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    References listed on IDEAS

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    1. Hou-Tong Chen & Willie J. Padilla & Joshua M. O. Zide & Arthur C. Gossard & Antoinette J. Taylor & Richard D. Averitt, 2006. "Active terahertz metamaterial devices," Nature, Nature, vol. 444(7119), pages 597-600, November.
    2. Jinjin Shen & Xiaoming Zhou & Yuanyue Shan & Huahua Yue & Ru Huang & Jiaming Hu & Da Xing, 2020. "Sensitive detection of a bacterial pathogen using allosteric probe-initiated catalysis and CRISPR-Cas13a amplification reaction," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
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