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Mitigation of SARS-CoV-2 transmission at a large public university

Author

Listed:
  • Diana Rose E. Ranoa

    (University of Illinois at Urbana-Champaign
    University of Illinois at Urbana Champaign
    University of Illinois at Urbana-Champaign)

  • Robin L. Holland

    (University of Illinois at Urbana-Champaign)

  • Fadi G. Alnaji

    (University of Illinois at Urbana-Champaign)

  • Kelsie J. Green

    (University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • Leyi Wang

    (University of Illinois at Urbana-Champaign)

  • Richard L. Fredrickson

    (University of Illinois at Urbana-Champaign)

  • Tong Wang

    (University of Illinois at Urbana-Champaign)

  • George N. Wong

    (University of Illinois at Urbana-Champaign)

  • Johnny Uelmen

    (University of Illinois at Urbana-Champaign)

  • Sergei Maslov

    (University of Illinois at Urbana Champaign
    University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • Zachary J. Weiner

    (University of Illinois at Urbana-Champaign)

  • Alexei V. Tkachenko

    (Brookhaven National Laboratory)

  • Hantao Zhang

    (University of Illinois at Urbana-Champaign)

  • Zhiru Liu

    (Stanford University)

  • Ahmed Ibrahim

    (University of Illinois at Urbana-Champaign)

  • Sanjay J. Patel

    (University of Illinois at Urbana-Champaign)

  • John M. Paul

    (University of Illinois Urbana-Champaign)

  • Nickolas P. Vance

    (University of Illinois at Urbana-Champaign)

  • Joseph G. Gulick

    (University of Illinois at Urbana-Champaign)

  • Sandeep Puthanveetil Satheesan

    (University of Illinois at Urbana-Champaign)

  • Isaac J. Galvan

    (University of Illinois at Urbana-Champaign)

  • Andrew Miller

    (University of Illinois at Urbana-Champaign)

  • Joseph Grohens

    (University of Illinois at Urbana-Champaign)

  • Todd J. Nelson

    (University of Illinois at Urbana-Champaign)

  • Mary P. Stevens

    (University of Illinois at Urbana-Champaign)

  • P Mark Hennessy

    (Inabyte)

  • Robert C. Parker

    (University of Illinois at Urbana-Champaign)

  • Edward Santos

    (OSF Healthcare)

  • Charles Brackett

    (OSF Healthcare)

  • Julie D. Steinman

    (University of Illinois at Urbana-Champaign)

  • Melvin R. Fenner

    (University of Illinois at Urbana-Champaign)

  • Kirstin Dohrer

    (University of Illinois at Urbana-Champaign)

  • Michael DeLorenzo

    (University of Illinois at Urbana-Champaign)

  • Laura Wilhelm-Barr

    (University of Illinois at Urbana-Champaign)

  • Brian R. Brauer

    (Illinois Fire Service Institute)

  • Catherine Best-Popescu

    (University of Illinois at Urbana-Champaign)

  • Gary Durack

    (University of Illinois Urbana-Champaign
    Tekmill)

  • Nathan Wetter

    (Tekmill)

  • David M. Kranz

    (University of Illinois at Urbana-Champaign)

  • Jessica Breitbarth

    (University of Illinois at Urbana-Champaign)

  • Charlie Simpson

    (University of Illinois at Urbana-Champaign)

  • Julie A. Pryde

    (Champaign-Urbana Public Health District)

  • Robin N. Kaler

    (University of Illinois at Urbana-Champaign)

  • Chris Harris

    (University of Illinois at Urbana-Champaign)

  • Allison C. Vance

    (University of Illinois at Urbana-Champaign)

  • Jodi L. Silotto

    (University of Illinois at Urbana-Champaign)

  • Mark Johnson

    (University of Illinois at Urbana-Champaign)

  • Enrique Andres Valera

    (University of Illinois at Urbana-Champaign
    University of Illinois Urbana-Champaign)

  • Patricia K. Anton

    (University of Illinois Urbana-Champaign)

  • Lowa Mwilambwe

    (University of Illinois Urbana-Champaign)

  • Stephen P. Bryan

    (University of Illinois at Urbana-Champaign)

  • Deborah S. Stone

    (University of Illinois at Urbana-Champaign)

  • Danita B. Young

    (University of Illinois Urbana-Champaign)

  • Wanda E. Ward

    (University of Illinois at Urbana-Champaign)

  • John Lantz

    (University of Illinois at Urbana-Champaign)

  • John A. Vozenilek

    (University of Illinois Urbana-Champaign)

  • Rashid Bashir

    (University of Illinois Urbana-Champaign)

  • Jeffrey S. Moore

    (University of Illinois at Urbana Champaign
    University of Illinois at Urbana-Champaign)

  • Mayank Garg

    (University of Illinois at Urbana-Champaign)

  • Julian C. Cooper

    (University of Illinois at Urbana-Champaign)

  • Gillian Snyder

    (University of Illinois at Urbana-Champaign)

  • Michelle H. Lore

    (University of Illinois at Urbana-Champaign)

  • Dustin L. Yocum

    (University of Illinois at Urbana-Champaign)

  • Neal J. Cohen

    (University of Illinois at Urbana-Champaign
    University of Illinois Urbana-Champaign)

  • Jan E. Novakofski

    (University of Illinois at Urbana-Champaign)

  • Melanie J. Loots

    (University of Illinois at Urbana-Champaign)

  • Randy L. Ballard

    (University of Illinois at Urbana-Champaign)

  • Mark Band

    (University of Illinois at Urbana-Champaign)

  • Kayla M. Banks

    (University of Illinois at Urbana-Champaign)

  • Joseph D. Barnes

    (University of Illinois Health)

  • Iuliana Bentea

    (University of Illinois at Chicago)

  • Jessica Black

    (University of Illinois Urbana-Champaign)

  • Jeremy Busch

    (University of Illinois at Urbana-Champaign)

  • Abigail Conte

    (Johns Hopkins Bloomberg School of Public Health)

  • Madison Conte

    (Johns Hopkins School of Medicine)

  • Michael Curry

    (University of Illinois Urbana-Champaign)

  • Jennifer Eardley

    (University of Illinois at Urbana-Champaign)

  • April Edwards

    (University of Illinois at Urbana-Champaign)

  • Therese Eggett

    (University of Illinois at Urbana-Champaign)

  • Judes Fleurimont

    (University of Illinois Health)

  • Delaney Foster

    (University of Illinois at Urbana-Champaign)

  • Bruce W. Fouke

    (University of Illinois at Urbana Champaign
    University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • Nicholas Gallagher

    (Johns Hopkins University School of Medicine)

  • Nicole Gastala

    (Johns Hopkins Bloomberg School of Public Health)

  • Scott A. Genung

    (University of Illinois at Urbana-Champaign)

  • Declan Glueck

    (University of Illinois Urbana-Champaign)

  • Brittani Gray

    (University of Illinois Health)

  • Andrew Greta

    (University of Illinois System Office)

  • Robert M. Healy

    (University of Illinois at Urbana-Champaign)

  • Ashley Hetrick

    (University of Wisconsin-Madison)

  • Arianna A. Holterman

    (University of Illinois at Urbana-Champaign)

  • Nahed Ismail

    (University of Illinois at Chicago)

  • Ian Jasenof

    (University of Illinois Health)

  • Patrick Kelly

    (University of Wisconsin-Madison)

  • Aaron Kielbasa

    (University of Illinois at Urbana-Champaign)

  • Teresa Kiesel

    (University of Wisconsin-Madison)

  • Lorenzo M. Kindle

    (University of Illinois at Urbana-Champaign)

  • Rhonda L. Lipking

    (University of Illinois at Urbana-Champaign)

  • Yukari C. Manabe

    (Johns Hopkins School of Medicine)

  • Jade ́ Mayes

    (University of Illinois at Urbana-Champaign)

  • Reubin McGuffin

    (University of Illinois at Urbana-Champaign)

  • Kenton G. McHenry

    (University of Illinois at Urbana-Champaign)

  • Agha Mirza

    (Johns Hopkins School of Medicine)

  • Jada Moseley

    (University of Illinois Urbana-Champaign)

  • Heba H. Mostafa

    (Johns Hopkins University School of Medicine)

  • Melody Mumford

    (University of Illinois Health)

  • Kathleen Munoz

    (University of Illinois Health)

  • Arika D. Murray

    (University of Illinois Urbana-Champaign)

  • Moira Nolan

    (University of Illinois at Urbana-Champaign)

  • Nil A. Parikh

    (University of Illinois at Urbana-Champaign)

  • Andrew Pekosz

    (Johns Hopkins Bloomberg School of Public Health
    Johns Hopkins School of Medicine)

  • Janna Pflugmacher

    (University Administration, University of Illinois at Urbana-Champaign)

  • Janise M. Phillips

    (University of Illinois at Urbana-Champaign)

  • Collin Pitts

    (University of Wisconsin-Madison)

  • Mark C. Potter

    (University of Illinois at Chicago)

  • James Quisenberry

    (University of Illinois at Urbana-Champaign)

  • Janelle Rear

    (University of Illinois System)

  • Matthew L. Robinson

    (Johns Hopkins School of Medicine)

  • Edith Rosillo

    (University of Illinois at Urbana-Champaign)

  • Leslie N. Rye

    (University of Illinois at Urbana-Champaign)

  • MaryEllen Sherwood

    (University of Illinois at Urbana-Champaign)

  • Anna Simon

    (University of Illinois at Urbana-Champaign)

  • Jamie M. Singson

    (University of Illinois at Urbana-Champaign)

  • Carly Skadden

    (University of Illinois at Urbana-Champaign)

  • Tina H. Skelton

    (University of Illinois at Urbana-Champaign)

  • Charlie Smith

    (University of Illinois at Urbana-Champaign)

  • Mary Stech

    (University of Illinois at Urbana-Champaign)

  • Ryan Thomas

    (University of Illinois at Urbana-Champaign)

  • Matthew A. Tomaszewski

    (University of Illinois at Urbana-Champaign)

  • Erika A. Tyburski

    (Children’s Healthcare of Atlanta, and Georgia Institute of Technology
    Institute for Electronics and Nanotechnology)

  • Scott Vanwingerden

    (University of Illinois at Urbana-Champaign)

  • Evette Vlach

    (University of Illinois at Urbana-Champaign)

  • Ronald S. Watkins

    (University of Illinois System Office
    University of Illinois System)

  • Karriem Watson

    (University of Illinois Health)

  • Karen C. White

    (University of Illinois at Urbana-Champaign)

  • Timothy L. Killeen

    (University of Illinois Urbana-Champaign)

  • Robert J. Jones

    (University of Illinois at Urbana-Champaign)

  • Andreas C. Cangellaris

    (University of Illinois Urbana-Champaign)

  • Susan A. Martinis

    (University of Illinois at Urbana-Champaign)

  • Awais Vaid

    (Champaign-Urbana Public Health District)

  • Christopher B. Brooke

    (University of Illinois at Urbana Champaign
    University of Illinois at Urbana-Champaign)

  • Joseph T. Walsh

    (University of Illinois at Urbana-Champaign)

  • Ahmed Elbanna

    (University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • William C. Sullivan

    (University of Illinois at Urbana-Champaign)

  • Rebecca L. Smith

    (University of Illinois at Urbana Champaign
    University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • Nigel Goldenfeld

    (University of Illinois at Urbana Champaign
    University of Illinois at Urbana-Champaign
    University of California San Diego)

  • Timothy M. Fan

    (University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • Paul J. Hergenrother

    (University of Illinois at Urbana-Champaign
    University of Illinois at Urbana Champaign
    University of Illinois at Urbana-Champaign)

  • Martin D. Burke

    (University of Illinois at Urbana-Champaign
    University of Illinois at Urbana Champaign
    University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

Abstract

In Fall 2020, universities saw extensive transmission of SARS-CoV-2 among their populations, threatening health of the university and surrounding communities, and viability of in-person instruction. Here we report a case study at the University of Illinois at Urbana-Champaign, where a multimodal “SHIELD: Target, Test, and Tell” program, with other non-pharmaceutical interventions, was employed to keep classrooms and laboratories open. The program included epidemiological modeling and surveillance, fast/frequent testing using a novel low-cost and scalable saliva-based RT-qPCR assay for SARS-CoV-2 that bypasses RNA extraction, called covidSHIELD, and digital tools for communication and compliance. In Fall 2020, we performed >1,000,000 covidSHIELD tests, positivity rates remained low, we had zero COVID-19-related hospitalizations or deaths amongst our university community, and mortality in the surrounding Champaign County was reduced more than 4-fold relative to expected. This case study shows that fast/frequent testing and other interventions mitigated transmission of SARS-CoV-2 at a large public university.

Suggested Citation

  • Diana Rose E. Ranoa & Robin L. Holland & Fadi G. Alnaji & Kelsie J. Green & Leyi Wang & Richard L. Fredrickson & Tong Wang & George N. Wong & Johnny Uelmen & Sergei Maslov & Zachary J. Weiner & Alexei, 2022. "Mitigation of SARS-CoV-2 transmission at a large public university," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30833-3
    DOI: 10.1038/s41467-022-30833-3
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    References listed on IDEAS

    as
    1. Baisheng Li & Aiping Deng & Kuibiao Li & Yao Hu & Zhencui Li & Yaling Shi & Qianling Xiong & Zhe Liu & Qianfang Guo & Lirong Zou & Huan Zhang & Meng Zhang & Fangzhu Ouyang & Juan Su & Wenzhe Su & Jing, 2022. "Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. Stephen M Kissler & Joseph R Fauver & Christina Mack & Scott W Olesen & Caroline Tai & Kristin Y Shiue & Chaney C Kalinich & Sarah Jednak & Isabel M Ott & Chantal B F Vogels & Jay Wohlgemuth & James W, 2021. "Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies," PLOS Biology, Public Library of Science, vol. 19(7), pages 1-17, July.
    3. Katelyn M Gostic & Lauren McGough & Edward B Baskerville & Sam Abbott & Keya Joshi & Christine Tedijanto & Rebecca Kahn & Rene Niehus & James A Hay & Pablo M De Salazar & Joel Hellewell & Sophie Meaki, 2020. "Practical considerations for measuring the effective reproductive number, Rt," PLOS Computational Biology, Public Library of Science, vol. 16(12), pages 1-21, December.
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