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Dichotomy of the BSL phosphatase signaling spatially regulates MAPK components in stomatal fate determination

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  • Xiaoyu Guo

    (The State University of New Jersey)

  • Xue Ding

    (The State University of New Jersey)

  • Juan Dong

    (The State University of New Jersey
    The State University of New Jersey)

Abstract

MAPK signaling modules play crucial roles in regulating numerous biological processes in all eukaryotic cells. How MAPK signaling specificity and strength are tightly controlled remains a major challenging question. In Arabidopsis stomatal development, the MAPKK Kinase YODA (YDA) functions at the cell periphery to inhibit stomatal production by activating MAPK 3 and 6 (MPK3/6) that directly phosphorylate stomatal fate-determining transcription factors for degradation in the nucleus. Recently, we demonstrated that BSL1, one of the four BSL protein phosphatases, localizes to the cell cortex to activate YDA, elevating MPK3/6 activity to suppress stomatal formation. Here, we showed that at the plasma membrane, all four members of BSL proteins contribute to the YDA activation. However, in the nucleus, specific BSL members (BSL2, BSL3, and BSU1) directly deactivate MPK6 to counteract the linear MAPK pathway, thereby promoting stomatal formation. Thus, the pivotal MAPK signaling in stomatal fate determination is spatially modulated by a signaling dichotomy of the BSL protein phosphatases in Arabidopsis, providing a prominent example of how MAPK activities are integrated and specified by signaling compartmentalization at the subcellular level.

Suggested Citation

  • Xiaoyu Guo & Xue Ding & Juan Dong, 2022. "Dichotomy of the BSL phosphatase signaling spatially regulates MAPK components in stomatal fate determination," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30254-2
    DOI: 10.1038/s41467-022-30254-2
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    References listed on IDEAS

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    1. Cora A. MacAlister & Kyoko Ohashi-Ito & Dominique C. Bergmann, 2007. "Transcription factor control of asymmetric cell divisions that establish the stomatal lineage," Nature, Nature, vol. 445(7127), pages 537-540, February.
    2. Tae-Wuk Kim & Marta Michniewicz & Dominique C. Bergmann & Zhi-Yong Wang, 2012. "Brassinosteroid regulates stomatal development by GSK3-mediated inhibition of a MAPK pathway," Nature, Nature, vol. 482(7385), pages 419-422, February.
    3. Anaxi Houbaert & Cheng Zhang & Manish Tiwari & Kun Wang & Alberto Marcos Serrano & Daniel V. Savatin & Mounashree J. Urs & Miroslava K. Zhiponova & Gustavo E. Gudesblat & Isabelle Vanhoutte & Dominiqu, 2018. "POLAR-guided signalling complex assembly and localization drive asymmetric cell division," Nature, Nature, vol. 563(7732), pages 574-578, November.
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