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WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour

Author

Listed:
  • Shiu-Ling Chen

    (National Chi Nan University)

  • Bo-Ting Liu

    (National Chi Nan University)

  • Wang-Pao Lee

    (College of Medicine, Chang Gung University)

  • Sin-Bo Liao

    (National Chi Nan University
    National Tsing Hua University)

  • Yao-Bang Deng

    (National Chi Nan University)

  • Chia-Lin Wu

    (College of Medicine, Chang Gung University
    Chang Gung Memorial Hospital
    National Tsing Hua University)

  • Shuk-Man Ho

    (National Chi Nan University)

  • Bing-Xian Shen

    (National Chi Nan University)

  • Guan-Hock Khoo

    (Tunghai University)

  • Wei-Chiang Shiu

    (National Chi Nan University)

  • Chih-Hsuan Chang

    (Tunghai University
    National Tsing Hua University
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes)

  • Hui-Wen Shih

    (Tunghai University)

  • Jung-Kun Wen

    (Institute of Biological Chemistry, Academia Sinica)

  • Tsuo-Hung Lan

    (School of Medicine, National Yang Ming Chiao Tung University
    Tsaotun Psychiatric Center, Ministry of Health and Welfare
    Taichung Veterans General Hospital
    Center for Neuropsychiatric Research, National Health Research Institutes)

  • Chih-Chien Lin

    (School of Medicine, National Yang Ming Chiao Tung University)

  • Yu-Chen Tsai

    (Tunghai University)

  • Huey-Fen Tzeng

    (National Chi Nan University)

  • Tsai-Feng Fu

    (National Chi Nan University)

Abstract

The nervous and endocrine systems coordinate with each other to closely influence physiological and behavioural responses in animals. Here we show that WAKE (encoded by wide awake, also known as wake) modulates membrane levels of GABAA receptor Resistance to Dieldrin (Rdl), in insulin-producing cells of adult male Drosophila melanogaster. This results in changes to secretion of insulin-like peptides which is associated with changes in juvenile hormone biosynthesis in the corpus allatum, which in turn leads to a decrease in 20-hydroxyecdysone levels. A reduction in ecdysone signalling changes neural architecture and lowers the perception of the male-specific sex pheromone 11-cis-vaccenyl acetate by odorant receptor 67d olfactory neurons. These finding explain why WAKE-deficient in Drosophila elicits significant male-male courtship behaviour.

Suggested Citation

  • Shiu-Ling Chen & Bo-Ting Liu & Wang-Pao Lee & Sin-Bo Liao & Yao-Bang Deng & Chia-Lin Wu & Shuk-Man Ho & Bing-Xian Shen & Guan-Hock Khoo & Wei-Chiang Shiu & Chih-Hsuan Chang & Hui-Wen Shih & Jung-Kun W, 2022. "WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30165-2
    DOI: 10.1038/s41467-022-30165-2
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    References listed on IDEAS

    as
    1. Shu-Yun Kuo & Chia-Lin Wu & Min-Yen Hsieh & Chen-Ta Lin & Rong-Kun Wen & Lien-Cheng Chen & Yu-Hui Chen & Yhu-Wei Yu & Horng-Dar Wang & Yi-Ju Su & Chun-Ju Lin & Cian-Yi Yang & Hsien-Yu Guan & Pei-Yu Wa, 2015. "PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
    2. Yael Grosjean & Raphael Rytz & Jean-Pierre Farine & Liliane Abuin & Jérôme Cortot & Gregory S. X. E. Jefferis & Richard Benton, 2011. "An olfactory receptor for food-derived odours promotes male courtship in Drosophila," Nature, Nature, vol. 478(7368), pages 236-240, October.
    3. Amina Kurtovic & Alexandre Widmer & Barry J. Dickson, 2007. "A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone," Nature, Nature, vol. 446(7135), pages 542-546, March.
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