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PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine

Author

Listed:
  • Shu-Yun Kuo

    (National Chi Nan University)

  • Chia-Lin Wu

    (College of Medicine, Chang Gung University
    Chang Gung Memorial Hospital)

  • Min-Yen Hsieh

    (National Chi Nan University)

  • Chen-Ta Lin

    (National Chi Nan University)

  • Rong-Kun Wen

    (National Chi Nan University)

  • Lien-Cheng Chen

    (Chung Hwa University of Medical Technology)

  • Yu-Hui Chen

    (National Chi Nan University)

  • Yhu-Wei Yu

    (National Chi Nan University)

  • Horng-Dar Wang

    (Institute of Biotechnology, Institute of Systems Neuroscience, National Tsing Hua University)

  • Yi-Ju Su

    (National Chi Nan University)

  • Chun-Ju Lin

    (National Chi Nan University)

  • Cian-Yi Yang

    (National Chi Nan University)

  • Hsien-Yu Guan

    (National Chi Nan University)

  • Pei-Yu Wang

    (Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University)

  • Tsuo-Hung Lan

    (School of Medicine, National Yang Ming University
    Taichung Veterans General Hospital)

  • Tsai-Feng Fu

    (National Chi Nan University)

Abstract

Male sexual desire typically declines with ageing. However, our understanding of the neurobiological basis for this phenomenon is limited by our knowledge of the brain circuitry and neuronal pathways controlling male sexual desire. A number of studies across species suggest that dopamine (DA) affects sexual desire. Here we use genetic tools and behavioural assays to identify a novel subset of DA neurons that regulate age-associated male courtship activity in Drosophila. We find that increasing DA levels in a subset of cells in the PPL2ab neuronal cluster is necessary and sufficient for increased sustained courtship in both young and aged male flies. Our results indicate that preventing the age-related decline in DA levels in PPL2ab neurons alleviates diminished courtship behaviours in male Drosophila. These results may provide the foundation for deciphering the circuitry involved in sexual motivation in the male Drosophila brain.

Suggested Citation

  • Shu-Yun Kuo & Chia-Lin Wu & Min-Yen Hsieh & Chen-Ta Lin & Rong-Kun Wen & Lien-Cheng Chen & Yu-Hui Chen & Yhu-Wei Yu & Horng-Dar Wang & Yi-Ju Su & Chun-Ju Lin & Cian-Yi Yang & Hsien-Yu Guan & Pei-Yu Wa, 2015. "PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8490
    DOI: 10.1038/ncomms8490
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    Cited by:

    1. Shiu-Ling Chen & Bo-Ting Liu & Wang-Pao Lee & Sin-Bo Liao & Yao-Bang Deng & Chia-Lin Wu & Shuk-Man Ho & Bing-Xian Shen & Guan-Hock Khoo & Wei-Chiang Shiu & Chih-Hsuan Chang & Hui-Wen Shih & Jung-Kun W, 2022. "WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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