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Coacervation in polyzwitterion-polyelectrolyte systems and their potential applications for gastrointestinal drug delivery platforms

Author

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  • Khatcher O. Margossian

    (University of Massachusetts
    Rush University Medical Center)

  • Marcel U. Brown

    (University of Massachusetts)

  • Todd Emrick

    (University of Massachusetts)

  • Murugappan Muthukumar

    (University of Massachusetts)

Abstract

Traditionally, complex coacervation is regarded as a process whereby two oppositely charged polyelectrolytes self-assemble into spherical droplets. Here, we introduce the polyzwitterionic complex, “pZC”, formed by the liquid-liquid phase separation of a polyzwitterion and a polyelectrolyte, and elucidate a mechanism by which such complexes can assemble using theory and experimental evidence. This system exhibits orthogonal phase behavior-it remains intact in acidic conditions, but disassembles as the pH increases, a process governed by the acid-base equilibria of the constituent chains. We relate the observed phase behavior to physiological conditions within the gastrointestinal tract with a simulation of the gastroduodenal junction, and demonstrate using video microscopy the viability of polyzwitterionic coacervates as technologies for the pH-triggered release of cargo. Such a system is envisaged to tackle imminent problems of drug transport via the oral route and serve as a packaging solution to increase uptake efficiency.

Suggested Citation

  • Khatcher O. Margossian & Marcel U. Brown & Todd Emrick & Murugappan Muthukumar, 2022. "Coacervation in polyzwitterion-polyelectrolyte systems and their potential applications for gastrointestinal drug delivery platforms," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29851-y
    DOI: 10.1038/s41467-022-29851-y
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    References listed on IDEAS

    as
    1. Li-Wei Chang & Tyler K. Lytle & Mithun Radhakrishna & Jason J. Madinya & Jon Vélez & Charles E. Sing & Sarah L. Perry, 2017. "Sequence and entropy-based control of complex coacervates," Nature Communications, Nature, vol. 8(1), pages 1-8, December.
    2. Sarah L. Perry & Lorraine Leon & Kyle Q. Hoffmann & Matthew J. Kade & Dimitrios Priftis & Katie A. Black & Derek Wong & Ryan A. Klein & Charles F. Pierce & Khatcher O. Margossian & Jonathan K. Whitmer, 2015. "Chirality-selected phase behaviour in ionic polypeptide complexes," Nature Communications, Nature, vol. 6(1), pages 1-8, May.
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    Cited by:

    1. Furqan Dar & Samuel R. Cohen & Diana M. Mitrea & Aaron H. Phillips & Gergely Nagy & Wellington C. Leite & Christopher B. Stanley & Jeong-Mo Choi & Richard W. Kriwacki & Rohit V. Pappu, 2024. "Biomolecular condensates form spatially inhomogeneous network fluids," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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