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Sequence and entropy-based control of complex coacervates

Author

Listed:
  • Li-Wei Chang

    (University of Massachusetts Amherst, Department of Chemical Engineering)

  • Tyler K. Lytle

    (University of Illinois at Urbana-Champaign, Department of Chemistry)

  • Mithun Radhakrishna

    (Indian Institute of Technology Gandhinagar, Department of Chemical Engineering)

  • Jason J. Madinya

    (University of Illinois at Urbana-Champaign, Department of Chemical and Biomolecular Engineering)

  • Jon Vélez

    (University of Massachusetts Amherst, Department of Chemical Engineering)

  • Charles E. Sing

    (University of Illinois at Urbana-Champaign, Department of Chemical and Biomolecular Engineering)

  • Sarah L. Perry

    (University of Massachusetts Amherst, Department of Chemical Engineering)

Abstract

Biomacromolecules rely on the precise placement of monomers to encode information for structure, function, and physiology. Efforts to emulate this complexity via the synthetic control of chemical sequence in polymers are finding success; however, there is little understanding of how to translate monomer sequence to physical material properties. Here we establish design rules for implementing this sequence-control in materials known as complex coacervates. These materials are formed by the associative phase separation of oppositely charged polyelectrolytes into polyelectrolyte dense (coacervate) and polyelectrolyte dilute (supernatant) phases. We demonstrate that patterns of charges can profoundly affect the charge–charge associations that drive this process. Furthermore, we establish the physical origin of this pattern-dependent interaction: there is a nuanced combination of structural changes in the dense coacervate phase and a 1D confinement of counterions due to patterns along polymers in the supernatant phase.

Suggested Citation

  • Li-Wei Chang & Tyler K. Lytle & Mithun Radhakrishna & Jason J. Madinya & Jon Vélez & Charles E. Sing & Sarah L. Perry, 2017. "Sequence and entropy-based control of complex coacervates," Nature Communications, Nature, vol. 8(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01249-1
    DOI: 10.1038/s41467-017-01249-1
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    Cited by:

    1. Aishwarya Agarwal & Lisha Arora & Sandeep K. Rai & Anamika Avni & Samrat Mukhopadhyay, 2022. "Spatiotemporal modulations in heterotypic condensates of prion and α-synuclein control phase transitions and amyloid conversion," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Yuri Hong & Saeed Najafi & Thomas Casey & Joan-Emma Shea & Song-I Han & Dong Soo Hwang, 2022. "Hydrophobicity of arginine leads to reentrant liquid-liquid phase separation behaviors of arginine-rich proteins," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Khatcher O. Margossian & Marcel U. Brown & Todd Emrick & Murugappan Muthukumar, 2022. "Coacervation in polyzwitterion-polyelectrolyte systems and their potential applications for gastrointestinal drug delivery platforms," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    4. Pengchao Zhao & Xianfeng Xia & Xiayi Xu & Kevin Kai Chung Leung & Aliza Rai & Yingrui Deng & Boguang Yang & Huasheng Lai & Xin Peng & Peng Shi & Honglu Zhang & Philip Wai Yan Chiu & Liming Bian, 2021. "Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    5. Anna C. Papageorgiou & Michaela Pospisilova & Jakub Cibulka & Raghib Ashraf & Christopher A. Waudby & Pavel Kadeřávek & Volha Maroz & Karel Kubicek & Zbynek Prokop & Lumir Krejci & Konstantinos Tripsi, 2023. "Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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