IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms7052.html
   My bibliography  Save this article

Chirality-selected phase behaviour in ionic polypeptide complexes

Author

Listed:
  • Sarah L. Perry

    (Institute for Molecular Engineering, University of Chicago)

  • Lorraine Leon

    (Institute for Molecular Engineering, University of Chicago
    Argonne National Laboratory)

  • Kyle Q. Hoffmann

    (Institute for Molecular Engineering, University of Chicago
    University of Wisconsin)

  • Matthew J. Kade

    (Institute for Molecular Engineering, University of Chicago
    Argonne National Laboratory)

  • Dimitrios Priftis

    (Institute for Molecular Engineering, University of Chicago)

  • Katie A. Black

    (University of California at Berkeley)

  • Derek Wong

    (Institute for Molecular Engineering, University of Chicago)

  • Ryan A. Klein

    (Institute for Molecular Engineering, University of Chicago)

  • Charles F. Pierce

    (Institute for Molecular Engineering, University of Chicago)

  • Khatcher O. Margossian

    (Institute for Molecular Engineering, University of Chicago)

  • Jonathan K. Whitmer

    (Institute for Molecular Engineering, University of Chicago
    Argonne National Laboratory)

  • Jian Qin

    (Institute for Molecular Engineering, University of Chicago)

  • Juan J. de Pablo

    (Institute for Molecular Engineering, University of Chicago
    Argonne National Laboratory)

  • Matthew Tirrell

    (Institute for Molecular Engineering, University of Chicago
    Argonne National Laboratory)

Abstract

Polyelectrolyte complexes present new opportunities for self-assembled soft matter. Factors determining whether the phase of the complex is solid or liquid remain unclear. Ionic polypeptides enable examination of the effects of stereochemistry on complex formation. Here we demonstrate that chirality determines the state of polyelectrolyte complexes, formed from mixing dilute solutions of oppositely charged polypeptides, via a combination of electrostatic and hydrogen-bonding interactions. Fluid complexes occur when at least one of the polypeptides in the mixture is racemic, which disrupts backbone hydrogen-bonding networks. Pairs of purely chiral polypeptides, of any sense, form compact, fibrillar solids with a β-sheet structure. Analogous behaviour occurs in micelles formed from polypeptide block copolymers with polyethylene oxide, where assembly into aggregates with either solid or fluid cores, and eventually into ordered phases at high concentrations, is possible. Chirality is an exploitable tool for manipulating material properties in polyelectrolyte complexation.

Suggested Citation

  • Sarah L. Perry & Lorraine Leon & Kyle Q. Hoffmann & Matthew J. Kade & Dimitrios Priftis & Katie A. Black & Derek Wong & Ryan A. Klein & Charles F. Pierce & Khatcher O. Margossian & Jonathan K. Whitmer, 2015. "Chirality-selected phase behaviour in ionic polypeptide complexes," Nature Communications, Nature, vol. 6(1), pages 1-8, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7052
    DOI: 10.1038/ncomms7052
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms7052
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms7052?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Takayuki Miki & Masahiro Hashimoto & Hiroki Takahashi & Masatoshi Shimizu & Sae Nakayama & Tadaomi Furuta & Hisakazu Mihara, 2024. "De novo designed YK peptides forming reversible amyloid for synthetic protein condensates in mammalian cells," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Khatcher O. Margossian & Marcel U. Brown & Todd Emrick & Murugappan Muthukumar, 2022. "Coacervation in polyzwitterion-polyelectrolyte systems and their potential applications for gastrointestinal drug delivery platforms," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7052. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.