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Identification of a protein responsible for the synthesis of archaeal membrane-spanning GDGT lipids

Author

Listed:
  • Zhirui Zeng

    (Southern University of Science and Technology
    Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou))

  • Huahui Chen

    (Southern University of Science and Technology)

  • Huan Yang

    (China University of Geosciences)

  • Yufei Chen

    (Southern University of Science and Technology)

  • Wei Yang

    (Southern University of Science and Technology)

  • Xi Feng

    (Southern University of Science and Technology)

  • Hongye Pei

    (China University of Geosciences)

  • Paula V. Welander

    (Stanford University)

Abstract

Glycerol dibiphytanyl glycerol tetraethers (GDGTs) are archaeal monolayer membrane lipids that can provide a competitive advantage in extreme environments. Here, we identify a radical SAM protein, tetraether synthase (Tes), that participates in the synthesis of GDGTs. Attempts to generate a tes-deleted mutant in Sulfolobus acidocaldarius were unsuccessful, suggesting that the gene is essential in this organism. Heterologous expression of tes homologues leads to production of GDGT and structurally related lipids in the methanogen Methanococcus maripaludis (which otherwise does not synthesize GDGTs and lacks a tes homolog, but produces a putative GDGT precursor, archaeol). Tes homologues are encoded in the genomes of many archaea, as well as in some bacteria, in which they might be involved in the synthesis of bacterial branched glycerol dialkyl glycerol tetraethers.

Suggested Citation

  • Zhirui Zeng & Huahui Chen & Huan Yang & Yufei Chen & Wei Yang & Xi Feng & Hongye Pei & Paula V. Welander, 2022. "Identification of a protein responsible for the synthesis of archaeal membrane-spanning GDGT lipids," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29264-x
    DOI: 10.1038/s41467-022-29264-x
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    1. Christian Rinke & Patrick Schwientek & Alexander Sczyrba & Natalia N. Ivanova & Iain J. Anderson & Jan-Fang Cheng & Aaron Darling & Stephanie Malfatti & Brandon K. Swan & Esther A. Gies & Jeremy A. Do, 2013. "Insights into the phylogeny and coding potential of microbial dark matter," Nature, Nature, vol. 499(7459), pages 431-437, July.
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    1. Yanan Li & Ting Yu & Xi Feng & Bo Zhao & Huahui Chen & Huan Yang & Xing Chen & Xiao-Hua Zhang & Hayden R. Anderson & Noah Z. Burns & Fuxing Zeng & Lizhi Tao & Zhirui Zeng, 2024. "Biosynthesis of GMGT lipids by a radical SAM enzyme associated with anaerobic archaea and oxygen-deficient environments," Nature Communications, Nature, vol. 15(1), pages 1-9, December.

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