IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-29191-x.html
   My bibliography  Save this article

Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox

Author

Listed:
  • Zhen-Xing Wang

    (Central South University
    Central South University)

  • Zhong-Wei Luo

    (Central South University
    Central South University)

  • Fu-Xing-Zi Li

    (Central South University)

  • Jia Cao

    (Central South University
    Central South University)

  • Shan-Shan Rao

    (Central South University
    Central South University)

  • Yi-Wei Liu

    (Central South University
    Central South University)

  • Yi-Yi Wang

    (Central South University
    Central South University)

  • Guo-Qiang Zhu

    (Central South University
    Central South University)

  • Jiang-Shan Gong

    (Central South University
    Central South University)

  • Jing-Tao Zou

    (Central South University
    Central South University)

  • Qiang Wang

    (Zhejiang University School of Medicine, Hangzhou)

  • Yi-Juan Tan

    (Central South University
    Central South University)

  • Yan Zhang

    (Central South University)

  • Yin Hu

    (Central South University)

  • You-You Li

    (Central South University
    Central South University)

  • Hao Yin

    (Central South University
    Central South University)

  • Xiao-Kai Wang

    (Central South University)

  • Ze-Hui He

    (Central South University
    Central South University)

  • Lu Ren

    (Central South University)

  • Zheng-Zhao Liu

    (Central South University
    Central South University
    Central South University
    Aging and Regenerative Medicine)

  • Xiong-Ke Hu

    (Central South University)

  • Ling-Qing Yuan

    (Central South University)

  • Ran Xu

    (Central South University)

  • Chun-Yuan Chen

    (Central South University
    Central South University)

  • Hui Xie

    (Central South University
    Central South University
    Central South University
    Central South University)

Abstract

Adipocyte differentiation of bone marrow mesenchymal stem/stromal cells (BMSCs) instead of osteoblast formation contributes to age- and menopause-related marrow adiposity and osteoporosis. Vascular calcification often occurs with osteoporosis, a contradictory association called “calcification paradox”. Here we show that extracellular vesicles derived from aged bone matrix (AB-EVs) during bone resorption favor BMSC adipogenesis rather than osteogenesis and augment calcification of vascular smooth muscle cells. Intravenous or intramedullary injection of AB-EVs promotes bone-fat imbalance and exacerbates Vitamin D3 (VD3)-induced vascular calcification in young or old mice. Alendronate (ALE), a bone resorption inhibitor, down-regulates AB-EVs release and attenuates aging- and ovariectomy-induced bone-fat imbalance. In the VD3-treated aged mice, ALE suppresses the ovariectomy-induced aggravation of vascular calcification. MiR-483-5p and miR-2861 are enriched in AB-EVs and essential for the AB-EVs-induced bone-fat imbalance and exacerbation of vascular calcification. Our study uncovers the role of AB-EVs as a messenger for calcification paradox by transferring miR-483-5p and miR-2861.

Suggested Citation

  • Zhen-Xing Wang & Zhong-Wei Luo & Fu-Xing-Zi Li & Jia Cao & Shan-Shan Rao & Yi-Wei Liu & Yi-Yi Wang & Guo-Qiang Zhu & Jiang-Shan Gong & Jing-Tao Zou & Qiang Wang & Yi-Juan Tan & Yan Zhang & Yin Hu & Yo, 2022. "Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29191-x
    DOI: 10.1038/s41467-022-29191-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-29191-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-29191-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Yuqin Men & Julia Yelick & Shijie Jin & Yang Tian & Ming Sum R. Chiang & Haruki Higashimori & Eoin Brown & Rachel Jarvis & Yongjie Yang, 2019. "Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS," Nature Communications, Nature, vol. 10(1), pages 1-18, December.
    2. Duk-Hwa Kwon & Gwang Hyeon Eom & Jeong Hyeon Ko & Sera Shin & Hosouk Joung & Nakwon Choe & Yoon Seok Nam & Hyun-Ki Min & Taewon Kook & Somy Yoon & Wanseok Kang & Yong Sook Kim & Hyung Seok Kim & Hyuck, 2016. "MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification," Nature Communications, Nature, vol. 7(1), pages 1-14, April.
    3. Yalin Zhang & Min Soo Kim & Baosen Jia & Jingqi Yan & Juan Pablo Zuniga-Hertz & Cheng Han & Dongsheng Cai, 2017. "Hypothalamic stem cells control ageing speed partly through exosomal miRNAs," Nature, Nature, vol. 548(7665), pages 52-57, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Nicola Alessio & Anna Lisa Brigida & Gianfranco Peluso & Nicola Antonucci & Umberto Galderisi & Dario Siniscalco, 2020. "Stem Cell-Derived Exosomes in Autism Spectrum Disorder," IJERPH, MDPI, vol. 17(3), pages 1-10, February.
    2. Salman Sadullah Usmani & Hyun-Gug Jung & Qichao Zhang & Min Woo Kim & Yuna Choi & Ahmet Burak Caglayan & Dongsheng Cai, 2024. "Targeting the hypothalamus for modeling age-related DNA methylation and developing OXT-GnRH combinational therapy against Alzheimer’s disease-like pathologies in male mouse model," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Shijie Jin & Xuan Chen & Yang Tian & Rachel Jarvis & Vanessa Promes & Yongjie Yang, 2023. "Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Bárbara Adem & Nuno Bastos & Carolina F. Ruivo & Sara Sousa-Alves & Carolina Dias & Patrícia F. Vieira & Inês A. Batista & Bruno Cavadas & Dieter Saur & José C. Machado & Dawen Cai & Sonia A. Melo, 2024. "Exosomes define a local and systemic communication network in healthy pancreas and pancreatic ductal adenocarcinoma," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29191-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.