IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-29122-w.html
   My bibliography  Save this article

Trajectory of immune evasion and cancer progression in hepatocellular carcinoma

Author

Listed:
  • Phuong H. D. Nguyen

    (SingHealth-DukeNUS Academic Medical Centre)

  • Martin Wasser

    (SingHealth-DukeNUS Academic Medical Centre
    Duke-Nus Medical School)

  • Chong Teik Tan

    (National University of Singapore)

  • Chun Jye Lim

    (SingHealth-DukeNUS Academic Medical Centre)

  • Hannah L. H. Lai

    (Agency for Science, Technology and Research (A*STAR))

  • Justine Jia Wen Seow

    (Agency for Science, Technology and Research (A*STAR))

  • Ramanuj DasGupta

    (Agency for Science, Technology and Research (A*STAR))

  • Cheryl Z. J. Phua

    (Agency for Science, Technology and Research (A*STAR))

  • Siming Ma

    (Agency for Science, Technology and Research (A*STAR))

  • Jicheng Yang

    (Duke-Nus Medical School)

  • Sheena D/O Suthen

    (SingHealth-DukeNUS Academic Medical Centre)

  • Wai Leong Tam

    (Agency for Science, Technology and Research (A*STAR)
    Nanyang Technological University
    National University of Singapore
    National University of Singapore)

  • Tony K. H. Lim

    (Duke-Nus Medical School
    Singapore General Hospital)

  • Joe Yeong

    (Duke-Nus Medical School
    Singapore General Hospital
    Technology and Research (A*STAR))

  • Wei Qiang Leow

    (Duke-Nus Medical School
    Singapore General Hospital)

  • Yin Huei Pang

    (National University Hospital)

  • Gwyneth Soon

    (National University Hospital)

  • Tracy Jiezhen Loh

    (Singapore General Hospital)

  • Wei Keat Wan

    (Singapore General Hospital)

  • Chung Yip Chan

    (Duke-Nus Medical School
    Singapore General Hospital and National Cancer Centre Singapore)

  • Peng Chung Cheow

    (Duke-Nus Medical School
    Singapore General Hospital and National Cancer Centre Singapore)

  • Han Chong Toh

    (Duke-Nus Medical School
    National Cancer Centre Singapore)

  • Alfred Kow

    (University Surgical Cluster, National University Health System)

  • Yock Young Dan

    (National University of Singapore)

  • Juinn Huar Kam

    (Duke-Nus Medical School
    Singapore General Hospital and National Cancer Centre Singapore)

  • Shridhar Iyer

    (University Surgical Cluster, National University Health System)

  • Krishnakumar Madhavan

    (University Surgical Cluster, National University Health System)

  • Alexander Chung

    (Duke-Nus Medical School
    Singapore General Hospital and National Cancer Centre Singapore)

  • Glenn K. Bonney

    (University Surgical Cluster, National University Health System)

  • Brian K. P. Goh

    (Duke-Nus Medical School
    Singapore General Hospital and National Cancer Centre Singapore)

  • Naiyang Fu

    (Duke-Nus Medical School)

  • Victor C. Yu

    (National University of Singapore)

  • Weiwei Zhai

    (Agency for Science, Technology and Research (A*STAR)
    Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Salvatore Albani

    (SingHealth-DukeNUS Academic Medical Centre
    Duke-Nus Medical School)

  • Pierce K. H. Chow

    (Singapore General Hospital and National Cancer Centre Singapore
    SingHealth Duke-NUS Academic Medical Centre (AMC))

  • Valerie Chew

    (SingHealth-DukeNUS Academic Medical Centre
    Duke-Nus Medical School)

Abstract

Immune evasion is key to cancer initiation and later at metastasis, but its dynamics at intermediate stages, where potential therapeutic interventions could be applied, is undefined. Here we show, using multi-dimensional analyses of resected tumours, their adjacent non-tumour tissues and peripheral blood, that extensive immune remodelling takes place in patients with stage I to III hepatocellular carcinoma (HCC). We demonstrate the depletion of anti-tumoural immune subsets and accumulation of immunosuppressive or exhausted subsets along with reduced tumour infiltration of CD8 T cells peaking at stage II tumours. Corresponding transcriptomic modification occur in the genes related to antigen presentation, immune responses, and chemotaxis. The progressive immune evasion is validated in a murine model of HCC. Our results show evidence of ongoing tumour-immune co-evolution during HCC progression and offer insights into potential interventions to reverse, prevent or limit the progression of the disease.

Suggested Citation

  • Phuong H. D. Nguyen & Martin Wasser & Chong Teik Tan & Chun Jye Lim & Hannah L. H. Lai & Justine Jia Wen Seow & Ramanuj DasGupta & Cheryl Z. J. Phua & Siming Ma & Jicheng Yang & Sheena D/O Suthen & Wa, 2022. "Trajectory of immune evasion and cancer progression in hepatocellular carcinoma," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29122-w
    DOI: 10.1038/s41467-022-29122-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-29122-w
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-022-29122-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Rachel Rosenthal & Elizabeth Larose Cadieux & Roberto Salgado & Maise Al Bakir & David A. Moore & Crispin T. Hiley & Tom Lund & Miljana Tanić & James L. Reading & Kroopa Joshi & Jake Y. Henry & Ehsan , 2019. "Neoantigen-directed immune escape in lung cancer evolution," Nature, Nature, vol. 567(7749), pages 479-485, March.
    2. Céline Mascaux & Mihaela Angelova & Angela Vasaturo & Jennifer Beane & Kahkeshan Hijazi & Geraldine Anthoine & Bénédicte Buttard & Françoise Rothe & Karen Willard-Gallo & Annick Haller & Vincent Ninan, 2019. "Immune evasion before tumour invasion in early lung squamous carcinogenesis," Nature, Nature, vol. 571(7766), pages 570-575, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Chandler D. Gatenbee & Ann-Marie Baker & Ryan O. Schenck & Maximilian Strobl & Jeffrey West & Margarida P. Neves & Sara Yakub Hasan & Eszter Lakatos & Pierre Martinez & William C. H. Cross & Marnix Ja, 2022. "Immunosuppressive niche engineering at the onset of human colorectal cancer," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Philip East & Gavin P. Kelly & Dhruva Biswas & Michela Marani & David C. Hancock & Todd Creasy & Kris Sachsenmeier & Charles Swanton & Julian Downward & Sophie de Carné Trécesson, 2022. "RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Huapan Fang & Zhaopei Guo & Jie Chen & Lin Lin & Yingying Hu & Yanhui Li & Huayu Tian & Xuesi Chen, 2021. "Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    4. Tian-Yu Song & Min Long & Hai-Xin Zhao & Miao-Wen Zou & Hong-Jie Fan & Yang Liu & Chen-Lu Geng & Min-Fang Song & Yu-Feng Liu & Jun-Yi Chen & Yu-Lin Yang & Wen-Rong Zhou & Da-Wei Huang & Bo Peng & Zhen, 2021. "Tumor evolution selectively inactivates the core microRNA machinery for immune evasion," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    5. Sijia Cui & Nicholas McGranahan & Jing Gao & Peng Chen & Wei Jiang & Lingrong Yang & Li Ma & Junfang Liao & Tian Xie & Congying Xie & Tariq Enver & Shixiu Wu, 2023. "Tracking the evolution of esophageal squamous cell carcinoma under dynamic immune selection by multi-omics sequencing," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    6. Meng Nie & Ke Yao & Xinsheng Zhu & Na Chen & Nan Xiao & Yi Wang & Bo Peng & LiAng Yao & Peng Li & Peng Zhang & Zeping Hu, 2021. "Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    7. Juan Blanco-Heredia & Carla Anjos Souza & Juan L. Trincado & Maria Gonzalez-Cao & Samuel Gonçalves-Ribeiro & Sara Ruiz Gil & Dmytro Pravdyvets & Samandhy Cedeño & Maurizio Callari & Antonio Marra & An, 2024. "Converging and evolving immuno-genomic routes toward immune escape in breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    8. Ming Chen & Runzhe Chen & Ying Jin & Jun Li & Xin Hu & Jiexin Zhang & Junya Fujimoto & Shawna M. Hubert & Carl M. Gay & Bo Zhu & Yanhua Tian & Nicholas McGranahan & Won-Chul Lee & Julie George & Xiao , 2021. "Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29122-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.