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Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity

Author

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  • Chen Yang

    (National Institute on Drug Abuse, National Institutes of Health
    Tangdu Hospital, Fourth Military Medical University)

  • Yuzheng Hu

    (Zhejiang University
    National Institute on Drug Abuse, National Institutes of Health)

  • Aleksandr D. Talishinsky

    (National Institute on Drug Abuse, National Institutes of Health)

  • Christian T. Potter

    (National Institute on Drug Abuse, National Institutes of Health)

  • Coleman B. Calva

    (National Institute on Drug Abuse, National Institutes of Health)

  • Leslie A. Ramsey

    (National Institute on Drug Abuse, National Institutes of Health)

  • Andrew J. Kesner

    (National Institute on Drug Abuse, National Institutes of Health)

  • Reuben F. Don

    (National Institute on Drug Abuse, National Institutes of Health)

  • Sue Junn

    (National Institute on Drug Abuse, National Institutes of Health)

  • Aaron Tan

    (National Institute on Drug Abuse, National Institutes of Health)

  • Anne F. Pierce

    (National Institute on Drug Abuse, National Institutes of Health)

  • Céline Nicolas

    (National Institute on Drug Abuse, National Institutes of Health)

  • Yosuke Arima

    (National Institute on Drug Abuse, National Institutes of Health)

  • Seung-Chan Lee

    (National Institute on Drug Abuse, National Institutes of Health)

  • Conghui Su

    (Zhejiang University)

  • Jensine M. Coudriet

    (National Institute on Drug Abuse, National Institutes of Health)

  • Carlos A. Mejia-Aponte

    (National Institute on Drug Abuse, National Institutes of Health)

  • Dong V. Wang

    (National Institute on Drug Abuse, National Institutes of Health)

  • Hanbing Lu

    (National Institute on Drug Abuse, National Institutes of Health)

  • Yihong Yang

    (National Institute on Drug Abuse, National Institutes of Health)

  • Satoshi Ikemoto

    (National Institute on Drug Abuse, National Institutes of Health)

Abstract

The prefrontal cortex is involved in goal-directed behavior. Here, we investigate circuits of the PFC regulating motivation, reinforcement, and its relationship to dopamine neuron activity. Stimulation of medial PFC (mPFC) neurons in mice activated many downstream regions, as shown by fMRI. Axonal terminal stimulation of mPFC neurons in downstream regions, including the anteromedial thalamic nucleus (AM), reinforced behavior and activated midbrain dopaminergic neurons. The stimulation of AM neurons projecting to the mPFC also reinforced behavior and activated dopamine neurons, and mPFC and AM showed a positive-feedback loop organization. We also found using fMRI in human participants watching reinforcing video clips that there is reciprocal excitatory functional connectivity, as well as co-activation of the two regions. Our results suggest that this cortico-thalamic loop regulates motivation, reinforcement, and dopaminergic neuron activity.

Suggested Citation

  • Chen Yang & Yuzheng Hu & Aleksandr D. Talishinsky & Christian T. Potter & Coleman B. Calva & Leslie A. Ramsey & Andrew J. Kesner & Reuben F. Don & Sue Junn & Aaron Tan & Anne F. Pierce & Céline Nicola, 2022. "Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28892-7
    DOI: 10.1038/s41467-022-28892-7
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    References listed on IDEAS

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    1. Wayne C. Drevets & Joseph L. Price & Joseph R. Simpson & Richard D. Todd & Theodore Reich & Michael Vannier & Marcus E. Raichle, 1997. "Subgenual prefrontal cortex abnormalities in mood disorders," Nature, Nature, vol. 386(6627), pages 824-827, April.
    2. Seung Wook Oh & Julie A. Harris & Lydia Ng & Brent Winslow & Nicholas Cain & Stefan Mihalas & Quanxin Wang & Chris Lau & Leonard Kuan & Alex M. Henry & Marty T. Mortrud & Benjamin Ouellette & Thuc Ngh, 2014. "A mesoscale connectome of the mouse brain," Nature, Nature, vol. 508(7495), pages 207-214, April.
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