IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-28892-7.html
   My bibliography  Save this article

Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity

Author

Listed:
  • Chen Yang

    (National Institute on Drug Abuse, National Institutes of Health
    Tangdu Hospital, Fourth Military Medical University)

  • Yuzheng Hu

    (Zhejiang University
    National Institute on Drug Abuse, National Institutes of Health)

  • Aleksandr D. Talishinsky

    (National Institute on Drug Abuse, National Institutes of Health)

  • Christian T. Potter

    (National Institute on Drug Abuse, National Institutes of Health)

  • Coleman B. Calva

    (National Institute on Drug Abuse, National Institutes of Health)

  • Leslie A. Ramsey

    (National Institute on Drug Abuse, National Institutes of Health)

  • Andrew J. Kesner

    (National Institute on Drug Abuse, National Institutes of Health)

  • Reuben F. Don

    (National Institute on Drug Abuse, National Institutes of Health)

  • Sue Junn

    (National Institute on Drug Abuse, National Institutes of Health)

  • Aaron Tan

    (National Institute on Drug Abuse, National Institutes of Health)

  • Anne F. Pierce

    (National Institute on Drug Abuse, National Institutes of Health)

  • Céline Nicolas

    (National Institute on Drug Abuse, National Institutes of Health)

  • Yosuke Arima

    (National Institute on Drug Abuse, National Institutes of Health)

  • Seung-Chan Lee

    (National Institute on Drug Abuse, National Institutes of Health)

  • Conghui Su

    (Zhejiang University)

  • Jensine M. Coudriet

    (National Institute on Drug Abuse, National Institutes of Health)

  • Carlos A. Mejia-Aponte

    (National Institute on Drug Abuse, National Institutes of Health)

  • Dong V. Wang

    (National Institute on Drug Abuse, National Institutes of Health)

  • Hanbing Lu

    (National Institute on Drug Abuse, National Institutes of Health)

  • Yihong Yang

    (National Institute on Drug Abuse, National Institutes of Health)

  • Satoshi Ikemoto

    (National Institute on Drug Abuse, National Institutes of Health)

Abstract

The prefrontal cortex is involved in goal-directed behavior. Here, we investigate circuits of the PFC regulating motivation, reinforcement, and its relationship to dopamine neuron activity. Stimulation of medial PFC (mPFC) neurons in mice activated many downstream regions, as shown by fMRI. Axonal terminal stimulation of mPFC neurons in downstream regions, including the anteromedial thalamic nucleus (AM), reinforced behavior and activated midbrain dopaminergic neurons. The stimulation of AM neurons projecting to the mPFC also reinforced behavior and activated dopamine neurons, and mPFC and AM showed a positive-feedback loop organization. We also found using fMRI in human participants watching reinforcing video clips that there is reciprocal excitatory functional connectivity, as well as co-activation of the two regions. Our results suggest that this cortico-thalamic loop regulates motivation, reinforcement, and dopaminergic neuron activity.

Suggested Citation

  • Chen Yang & Yuzheng Hu & Aleksandr D. Talishinsky & Christian T. Potter & Coleman B. Calva & Leslie A. Ramsey & Andrew J. Kesner & Reuben F. Don & Sue Junn & Aaron Tan & Anne F. Pierce & Céline Nicola, 2022. "Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28892-7
    DOI: 10.1038/s41467-022-28892-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-28892-7
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-28892-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Wayne C. Drevets & Joseph L. Price & Joseph R. Simpson & Richard D. Todd & Theodore Reich & Michael Vannier & Marcus E. Raichle, 1997. "Subgenual prefrontal cortex abnormalities in mood disorders," Nature, Nature, vol. 386(6627), pages 824-827, April.
    2. Seung Wook Oh & Julie A. Harris & Lydia Ng & Brent Winslow & Nicholas Cain & Stefan Mihalas & Quanxin Wang & Chris Lau & Leonard Kuan & Alex M. Henry & Marty T. Mortrud & Benjamin Ouellette & Thuc Ngh, 2014. "A mesoscale connectome of the mouse brain," Nature, Nature, vol. 508(7495), pages 207-214, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Wenqi Chen & Jiejunyi Liang & Qiyun Wu & Yunyun Han, 2024. "Anterior cingulate cortex provides the neural substrates for feedback-driven iteration of decision and value representation," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Wen-Hao Zhang & Si Wu & Krešimir Josić & Brent Doiron, 2023. "Sampling-based Bayesian inference in recurrent circuits of stochastic spiking neurons," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Alessandra Griffa & Mathieu Mach & Julien Dedelley & Daniel Gutierrez-Barragan & Alessandro Gozzi & Gilles Allali & Joanes Grandjean & Dimitri Ville & Enrico Amico, 2023. "Evidence for increased parallel information transmission in human brain networks compared to macaques and male mice," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Marcus N. Leiwe & Satoshi Fujimoto & Toshikazu Baba & Daichi Moriyasu & Biswanath Saha & Richi Sakaguchi & Shigenori Inagaki & Takeshi Imai, 2024. "Automated neuronal reconstruction with super-multicolour Tetbow labelling and threshold-based clustering of colour hues," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    5. Xin Zhang & Yan Xu & Lian Zhou & Chengcheng Zhang & Qingtao Meng & Shenshen Wu & Shizhi Wang & Zhen Ding & Xiaodong Chen & Xiaobo Li & Rui Chen, 2015. "Sex-Dependent Depression-Like Behavior Induced by Respiratory Administration of Aluminum Oxide Nanoparticles," IJERPH, MDPI, vol. 12(12), pages 1-14, December.
    6. Marghoti, Gabriel & de Lima Prado, Thiago & Conte, Arturo Cagnato & Ferrari, Fabiano Alan Serafim & Lopes, Sergio Roberto, 2022. "Intermittent chimera-like and bi-stable synchronization states in network of distinct Izhikevich neurons," Chaos, Solitons & Fractals, Elsevier, vol. 162(C).
    7. Vincent Paget-Blanc & Marlene E. Pfeffer & Marie Pronot & Paul Lapios & Maria-Florencia Angelo & Roman Walle & Fabrice P. Cordelières & Florian Levet & Stéphane Claverol & Sabrina Lacomme & Mélina Pet, 2022. "A synaptomic analysis reveals dopamine hub synapses in the mouse striatum," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    8. Harry Carey & Michael Pegios & Lewis Martin & Chris Saleeba & Anita J. Turner & Nicholas A. Everett & Ingvild E. Bjerke & Maja A. Puchades & Jan G. Bjaalie & Simon McMullan, 2023. "DeepSlice: rapid fully automatic registration of mouse brain imaging to a volumetric atlas," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    9. Peng Liu, 2024. "Antinetwork among China A-shares," Papers 2404.00028, arXiv.org.
    10. Minghao Dong & Ling Zhao & Kai Yuan & Fang Zeng & Jinbo Sun & Jixin Liu & Dahua Yu & Karen M von Deneen & Fanrong Liang & Wei Qin & Jie Tian, 2013. "Length of Acupuncture Training and Structural Plastic Brain Changes in Professional Acupuncturists," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-8, June.
    11. Xuandi Hou & Jianing Jing & Yizhou Jiang & Xiaohui Huang & Quanxiang Xian & Ting Lei & Jiejun Zhu & Kin Fung Wong & Xinyi Zhao & Min Su & Danni Li & Langzhou Liu & Zhihai Qiu & Lei Sun, 2024. "Nanobubble-actuated ultrasound neuromodulation for selectively shaping behavior in mice," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    12. Dongsheng Xiao & Brandon J. Forys & Matthieu P. Vanni & Timothy H. Murphy, 2021. "MesoNet allows automated scaling and segmentation of mouse mesoscale cortical maps using machine learning," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    13. Yao Fei & Qihang Wu & Shijie Zhao & Kun Song & Junwei Han & Cirong Liu, 2024. "Diverse and asymmetric patterns of single-neuron projectome in regulating interhemispheric connectivity," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    14. Ayelet M. Rosenberg & Manish Saggar & Anna S. Monzel & Jack Devine & Peter Rogu & Aaron Limoges & Alex Junker & Carmen Sandi & Eugene V. Mosharov & Dani Dumitriu & Christoph Anacker & Martin Picard, 2023. "Brain mitochondrial diversity and network organization predict anxiety-like behavior in male mice," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    15. Joseph W. Arthurs & Anna J. Bowen & Richard D. Palmiter & Nathan A. Baertsch, 2023. "Parabrachial tachykinin1-expressing neurons involved in state-dependent breathing control," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    16. Daniel G. Taub & Qiufen Jiang & Francesca Pietrafesa & Junfeng Su & Aloe Carroll & Caitlin Greene & Michael R. Blanchard & Aakanksha Jain & Mahmoud El-Rifai & Alexis Callen & Katherine Yager & Clara C, 2024. "The secondary somatosensory cortex gates mechanical and heat sensitivity," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    17. Sudesna Chakraborty & Roy A. M. Haast & Kate M. Onuska & Prabesh Kanel & Marco A. M. Prado & Vania F. Prado & Ali R. Khan & Taylor W. Schmitz, 2024. "Multimodal gradients of basal forebrain connectivity across the neocortex," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    18. Jun Ding & Jian Ji & Zachary Rabow & Tong Shen & Jacob Folz & Christopher R. Brydges & Sili Fan & Xinchen Lu & Sajjan Mehta & Megan R. Showalter & Ying Zhang & Renee Araiza & Lynette R. Bower & K. C. , 2021. "A metabolome atlas of the aging mouse brain," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    19. Xin Wei Chia & Jian Kwang Tan & Lee Fang Ang & Tsukasa Kamigaki & Hiroshi Makino, 2023. "Emergence of cortical network motifs for short-term memory during learning," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    20. Meng Wang & Ke Liu & Junxia Pan & Jialin Li & Pei Sun & Yongsheng Zhang & Longhui Li & Wenyan Guo & Qianqian Xin & Zhikai Zhao & Yurong Liu & Zhenqiao Zhou & Jing Lyu & Ting Zheng & Yunyun Han & Chunq, 2022. "Brain-wide projection reconstruction of single functionally defined neurons," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28892-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.