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Sex-Dependent Depression-Like Behavior Induced by Respiratory Administration of Aluminum Oxide Nanoparticles

Author

Listed:
  • Xin Zhang

    (Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China
    These authors contributed equally to this work.)

  • Yan Xu

    (Department of Environmental Health and Endemic Disease Control, Jiangsu Provincial, Center for Disease Prevention and Control, Nanjing 210009, China
    These authors contributed equally to this work.)

  • Lian Zhou

    (Department of Environmental Health and Endemic Disease Control, Jiangsu Provincial, Center for Disease Prevention and Control, Nanjing 210009, China)

  • Chengcheng Zhang

    (Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China)

  • Qingtao Meng

    (Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China)

  • Shenshen Wu

    (Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China)

  • Shizhi Wang

    (Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China)

  • Zhen Ding

    (Department of Environmental Health and Endemic Disease Control, Jiangsu Provincial, Center for Disease Prevention and Control, Nanjing 210009, China)

  • Xiaodong Chen

    (Department of Environmental Health and Endemic Disease Control, Jiangsu Provincial, Center for Disease Prevention and Control, Nanjing 210009, China)

  • Xiaobo Li

    (Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China)

  • Rui Chen

    (Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China)

Abstract

Ultrafine aluminum oxide, which are abundant in ambient and involved occupational environments, are associated with neurobehavioral alterations. However, few studies have focused on the effect of sex differences following exposure to environmental Al 2 O 3 ultrafine particles. In the present study, male and female mice were exposed to Al 2 O 3 nanoparticles (NPs) through a respiratory route. Only the female mice showed depression-like behavior. Although no obvious pathological changes were observed in mice brain tissues, the neurotransmitter and voltage-gated ion channel related gene expression, as well as the small molecule metabolites in the cerebral cortex, were differentially modulated between male and female mice. Both mental disorder-involved gene expression levels and metabolomics analysis results strongly suggested that glutamate pathways were implicated in sex differentiation induced by Al 2 O 3 NPs. Results demonstrated the potential mechanism of environmental ultrafine particle-induced depression-like behavior and the importance of sex dimorphism in the toxic research of environmental chemicals.

Suggested Citation

  • Xin Zhang & Yan Xu & Lian Zhou & Chengcheng Zhang & Qingtao Meng & Shenshen Wu & Shizhi Wang & Zhen Ding & Xiaodong Chen & Xiaobo Li & Rui Chen, 2015. "Sex-Dependent Depression-Like Behavior Induced by Respiratory Administration of Aluminum Oxide Nanoparticles," IJERPH, MDPI, vol. 12(12), pages 1-14, December.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:12:p:15011-15705:d:60326
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    References listed on IDEAS

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    1. Wayne C. Drevets & Joseph L. Price & Joseph R. Simpson & Richard D. Todd & Theodore Reich & Michael Vannier & Marcus E. Raichle, 1997. "Subgenual prefrontal cortex abnormalities in mood disorders," Nature, Nature, vol. 386(6627), pages 824-827, April.
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