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Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats

Author

Listed:
  • Yuni Kay

    (University of Southern California)

  • Linda Tsan

    (University of Southern California)

  • Elizabeth A. Davis

    (University of Southern California)

  • Chen Tian

    (University of Southern California)

  • Léa Décarie-Spain

    (University of Southern California)

  • Anastasiia Sadybekov

    (University of Southern California)

  • Anna N. Pushkin

    (University of Southern California)

  • Vsevolod Katritch

    (University of Southern California
    University of Southern California)

  • Scott E. Kanoski

    (University of Southern California
    University of Southern California)

  • Bruce E. Herring

    (University of Southern California
    University of Southern California)

Abstract

Mutations in the putative glutamatergic synapse scaffolding protein SAP97 are associated with the development of schizophrenia in humans. However, the role of SAP97 in synaptic regulation is unclear. Here we show that SAP97 is expressed in the dendrites of granule neurons in the dentate gyrus but not in the dendrites of other hippocampal neurons. Schizophrenia-related perturbations of SAP97 did not affect CA1 pyramidal neuron synapse function. Conversely, these perturbations produce dramatic augmentation of glutamatergic neurotransmission in granule neurons that can be attributed to a release of perisynaptic GluA1-containing AMPA receptors into the postsynaptic densities of perforant pathway synapses. Furthermore, inhibiting SAP97 function in the dentate gyrus was sufficient to impair contextual episodic memory. Together, our results identify a cell-type-specific synaptic regulatory mechanism in the dentate gyrus that, when disrupted, impairs contextual information processing in rats.

Suggested Citation

  • Yuni Kay & Linda Tsan & Elizabeth A. Davis & Chen Tian & Léa Décarie-Spain & Anastasiia Sadybekov & Anna N. Pushkin & Vsevolod Katritch & Scott E. Kanoski & Bruce E. Herring, 2022. "Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28430-5
    DOI: 10.1038/s41467-022-28430-5
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    References listed on IDEAS

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    1. Menachem Fromer & Andrew J. Pocklington & David H. Kavanagh & Hywel J. Williams & Sarah Dwyer & Padhraig Gormley & Lyudmila Georgieva & Elliott Rees & Priit Palta & Douglas M. Ruderfer & Noa Carrera &, 2014. "De novo mutations in schizophrenia implicate synaptic networks," Nature, Nature, vol. 506(7487), pages 179-184, February.
    2. Adam J. Granger & Yun Shi & Wei Lu & Manuel Cerpas & Roger A. Nicoll, 2013. "LTP requires a reserve pool of glutamate receptors independent of subunit type," Nature, Nature, vol. 493(7433), pages 495-500, January.
    3. Shaun M. Purcell & Jennifer L. Moran & Menachem Fromer & Douglas Ruderfer & Nadia Solovieff & Panos Roussos & Colm O’Dushlaine & Kimberly Chambert & Sarah E. Bergen & Anna Kähler & Laramie Duncan & El, 2014. "A polygenic burden of rare disruptive mutations in schizophrenia," Nature, Nature, vol. 506(7487), pages 185-190, February.
    4. Anastasiia Sadybekov & Chen Tian & Cosimo Arnesano & Vsevolod Katritch & Bruce E. Herring, 2017. "An autism spectrum disorder-related de novo mutation hotspot discovered in the GEF1 domain of Trio," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
    5. Andrea N. Suarez & Ted M. Hsu & Clarissa M. Liu & Emily E. Noble & Alyssa M. Cortella & Emily M. Nakamoto & Joel D. Hahn & Guillaume Lartigue & Scott E. Kanoski, 2018. "Gut vagal sensory signaling regulates hippocampus function through multi-order pathways," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
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