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Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity

Author

Listed:
  • Christina Kyrousi

    (Max Planck Institute of Psychiatry
    Neurosciences and Precision Medicine Research Institute “Costas Stefanis”)

  • Adam C. O’Neill

    (University of Otago)

  • Agnieska Brazovskaja

    (Max Planck Institute for Evolutionary Anthropology)

  • Zhisong He

    (Max Planck Institute for Evolutionary Anthropology
    ETH Zurich, Department of Biosystems Science and Engineering)

  • Pavel Kielkowski

    (Technische Universität München
    Department Chemie Ludwig-Maximilians-Universität München Butenandtstr. 5-13)

  • Laure Coquand

    (CNRS, UMR 144, 26 rue d’Ulm)

  • Rossella Giaimo

    (Max Planck Institute of Psychiatry
    University of Naples Federico II)

  • Pierpaolo D’ Andrea

    (Max Planck Institute of Psychiatry)

  • Alexander Belka

    (Max Planck Institute of Psychiatry)

  • Andrea Forero Echeverry

    (Max Planck Institute of Psychiatry)

  • Davide Mei

    (Children’s Hospital A. Meyer-University of Florence)

  • Matteo Lenge

    (Children’s Hospital A. Meyer-University of Florence)

  • Cristiana Cruceanu

    (Max Planck Institute of Psychiatry)

  • Isabel Y. Buchsbaum

    (Max Planck Institute of Psychiatry
    Ludwig-Maximilians-University)

  • Shahryar Khattak

    (School of Medicine, Technical University Dresden
    Royal College of Surgeons Ireland (RCSI) in Bahrain)

  • Guimiot Fabien

    (Unité de Foetopathologie, Assistance Publique-Hôpitaux de Paris, CHU Robert Debré)

  • Elisabeth Binder

    (Max Planck Institute of Psychiatry)

  • Frances Elmslie

    (University of London)

  • Renzo Guerrini

    (Children’s Hospital A. Meyer-University of Florence)

  • Alexandre D. Baffet

    (CNRS, UMR 144, 26 rue d’Ulm)

  • Stephan A. Sieber

    (Technische Universität München)

  • Barbara Treutlein

    (Max Planck Institute for Evolutionary Anthropology
    ETH Zurich, Department of Biosystems Science and Engineering)

  • Stephen P. Robertson

    (University of Otago)

  • Silvia Cappello

    (Max Planck Institute of Psychiatry)

Abstract

Basal progenitors (BPs), including intermediate progenitors and basal radial glia, are generated from apical radial glia and are enriched in gyrencephalic species like humans, contributing to neuronal expansion. Shortly after generation, BPs delaminate towards the subventricular zone, where they further proliferate before differentiation. Gene expression alterations involved in BP delamination and function in humans are poorly understood. Here, we study the role of LGALS3BP, so far known as a cancer biomarker, which is a secreted protein enriched in human neural progenitors (NPCs). We show that individuals with LGALS3BP de novo variants exhibit altered local gyrification, sulcal depth, surface area and thickness in their cortex. Additionally, using cerebral organoids, human fetal tissues and mice, we show that LGALS3BP regulates the position of NPCs. Single-cell RNA-sequencing and proteomics reveal that LGALS3BP-mediated mechanisms involve the extracellular matrix in NPCs’ anchoring and migration within the human brain. We propose that its temporal expression influences NPCs’ delamination, corticogenesis and gyrification extrinsically.

Suggested Citation

  • Christina Kyrousi & Adam C. O’Neill & Agnieska Brazovskaja & Zhisong He & Pavel Kielkowski & Laure Coquand & Rossella Giaimo & Pierpaolo D’ Andrea & Alexander Belka & Andrea Forero Echeverry & Davide , 2021. "Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity," Nature Communications, Nature, vol. 12(1), pages 1-22, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26447-w
    DOI: 10.1038/s41467-021-26447-w
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    References listed on IDEAS

    as
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