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Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

Author

Listed:
  • Dinesh Aggarwal

    (University of Cambridge, Department of Medicine
    Public Health England
    Cambridge University Hospital NHS Foundation Trust
    Wellcome Sanger Institute, Hinxton)

  • Andrew J. Page

    (Quadram Institute Bioscience, Norwich Research Park)

  • Ulf Schaefer

    (Public Health England)

  • George M. Savva

    (Quadram Institute Bioscience, Norwich Research Park)

  • Richard Myers

    (Public Health England)

  • Erik Volz

    (Imperial College London, Department of Infectious Disease Epidemiology)

  • Nicholas Ellaby

    (Public Health England)

  • Steven Platt

    (Public Health England)

  • Natalie Groves

    (Public Health England)

  • Eileen Gallagher

    (Public Health England)

  • Niamh M. Tumelty

    (University of Cambridge, Cambridge University Libraries)

  • Thanh Viet

    (Quadram Institute Bioscience, Norwich Research Park)

  • Gareth J. Hughes

    (Public Health England National Infections Service, Field Service)

  • Cong Chen

    (Public Health England)

  • Charlie Turner

    (Public Health England)

  • Sophie Logan

    (Public Health England, National Infections Service, Field Service)

  • Abbie Harrison

    (Public Health England)

  • Sharon J. Peacock

    (University of Cambridge, Department of Medicine
    Public Health England
    Cambridge University Hospital NHS Foundation Trust
    Wellcome Sanger Institute, Hinxton)

  • Meera Chand

    (Public Health England)

  • Ewan M. Harrison

    (University of Cambridge, Department of Medicine
    Public Health England
    Wellcome Sanger Institute, Hinxton
    University of Cambridge, Department of Public Health and Primary Care)

Abstract

Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16–20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique to identify travel-related clusters. Fewer genomically-linked cases were observed for index cases who returned from countries with quarantine requirement compared to countries with no quarantine requirement. This difference was explained by fewer importation events per identified genome for these cases, as opposed to fewer onward contacts per case. Overall, our study demonstrates that a 14-day quarantine period reduces, but does not completely eliminate, the onward transmission of imported cases, mainly by dissuading travel to countries with a quarantine requirement.

Suggested Citation

  • Dinesh Aggarwal & Andrew J. Page & Ulf Schaefer & George M. Savva & Richard Myers & Erik Volz & Nicholas Ellaby & Steven Platt & Natalie Groves & Eileen Gallagher & Niamh M. Tumelty & Thanh Viet & Gar, 2022. "Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28371-z
    DOI: 10.1038/s41467-022-28371-z
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    References listed on IDEAS

    as
    1. Torsten Seemann & Courtney R. Lane & Norelle L. Sherry & Sebastian Duchene & Anders Gonçalves da Silva & Leon Caly & Michelle Sait & Susan A. Ballard & Kristy Horan & Mark B. Schultz & Tuyet Hoang & M, 2020. "Tracking the COVID-19 pandemic in Australia using genomics," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    2. Pengcheng Du & Nan Ding & Jiarui Li & Fujie Zhang & Qi Wang & Zhihai Chen & Chuan Song & Kai Han & Wen Xie & Jingyuan Liu & Linghang Wang & Lirong Wei & Shanfang Ma & Mingxi Hua & Fengting Yu & Lin Wa, 2020. "Genomic surveillance of COVID-19 cases in Beijing," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
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