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A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating

Author

Listed:
  • Akinobu Suzuki

    (University of Toyama
    University of Toyama
    University of Toyama)

  • Sakurako Kosugi

    (University of Toyama
    University of Toyama)

  • Emi Murayama

    (University of Toyama
    University of Toyama
    University of Toyama)

  • Eri Sasakawa

    (University of Toyama)

  • Noriaki Ohkawa

    (University of Toyama
    University of Toyama
    PRESTO
    Dokkyo Medical University)

  • Ayumu Konno

    (Gunma University Graduate School of Medicine)

  • Hirokazu Hirai

    (Gunma University Graduate School of Medicine)

  • Kaoru Inokuchi

    (University of Toyama
    University of Toyama
    University of Toyama)

Abstract

When processing current sensory inputs, animals refer to related past experiences. Current information is then incorporated into the related neural network to update previously stored memories. However, the neuronal mechanism underlying the impact of memories of prior experiences on current learning is not well understood. Here, we found that a cellular ensemble in the posterior parietal cortex (PPC) that is activated during past experience mediates an interaction between past and current information to update memory through a PPC-anterior cingulate cortex circuit in mice. Moreover, optogenetic silencing of the PPC ensemble immediately after retrieval dissociated the interaction without affecting individual memories stored in the hippocampus and amygdala. Thus, a specific subpopulation of PPC cells represents past information and instructs downstream brain regions to update previous memories.

Suggested Citation

  • Akinobu Suzuki & Sakurako Kosugi & Emi Murayama & Eri Sasakawa & Noriaki Ohkawa & Ayumu Konno & Hirokazu Hirai & Kaoru Inokuchi, 2022. "A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27763-x
    DOI: 10.1038/s41467-021-27763-x
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    References listed on IDEAS

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    1. Denise J. Cai & Daniel Aharoni & Tristan Shuman & Justin Shobe & Jeremy Biane & Weilin Song & Brandon Wei & Michael Veshkini & Mimi La-Vu & Jerry Lou & Sergio E. Flores & Isaac Kim & Yoshitake Sano & , 2016. "A shared neural ensemble links distinct contextual memories encoded close in time," Nature, Nature, vol. 534(7605), pages 115-118, June.
    2. Masanori Nomoto & Noriaki Ohkawa & Hirofumi Nishizono & Jun Yokose & Akinobu Suzuki & Mina Matsuo & Shuhei Tsujimura & Yukari Takahashi & Masashi Nagase & Ayako M. Watabe & Fusao Kato & Kaoru Inokuchi, 2016. "Cellular tagging as a neural network mechanism for behavioural tagging," Nature Communications, Nature, vol. 7(1), pages 1-11, November.
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    1. Ruijie Li & Junjie Huang & Longhui Li & Zhikai Zhao & Susu Liang & Shanshan Liang & Meng Wang & Xiang Liao & Jing Lyu & Zhenqiao Zhou & Sibo Wang & Wenjun Jin & Haiyang Chen & Damaris Holder & Hongban, 2023. "Holistic bursting cells store long-term memory in auditory cortex," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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