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Self-activating anti-infection implant

Author

Listed:
  • Jieni Fu

    (Tianjin University)

  • Weidong Zhu

    (Hebei University of Technology
    Hubei University)

  • Xiangmei Liu

    (Hebei University of Technology)

  • Chunyong Liang

    (Hebei University of Technology)

  • Yufeng Zheng

    (Peking University)

  • Zhaoyang Li

    (Tianjin University)

  • Yanqin Liang

    (Tianjin University)

  • Dong Zheng

    (Huazhong University of Science and Technology)

  • Shengli Zhu

    (Tianjin University)

  • Zhenduo Cui

    (Tianjin University)

  • Shuilin Wu

    (Tianjin University
    Hubei University)

Abstract

Clinically, it is difficult to endow implants with excellent osteogenic ability and antibacterial activity simultaneously. Herein, the self-activating implants modified with hydroxyapatite (HA)/MoS2 coating are designed to prevent Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) infections and accelerate bone regeneration simultaneously. The electron transfer between bacteria and HA/MoS2 is triggered when bacteria contacted with the material. RNA sequencing data reveals that the expression level of anaerobic respiration–related genes is up-regulated and the expression level of aerobic respiration–related genes is down-regulated when bacteria adhere to the implants. HA/MoS2 presents a highly effective antibacterial efficacy against both S. aureus and E. coli because of bacterial respiration–activated metabolic pathway changes. Meanwhile, this coating promotes the osteoblastic differentiation of mesenchymal stem cells by altering the potentials of cell membrane and mitochondrial membrane. The proposed strategy exhibits great potential to endow implants with self-activating anti-infection performance and osteogenic ability simultaneously.

Suggested Citation

  • Jieni Fu & Weidong Zhu & Xiangmei Liu & Chunyong Liang & Yufeng Zheng & Zhaoyang Li & Yanqin Liang & Dong Zheng & Shengli Zhu & Zhenduo Cui & Shuilin Wu, 2021. "Self-activating anti-infection implant," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27217-4
    DOI: 10.1038/s41467-021-27217-4
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    References listed on IDEAS

    as
    1. Gemma Reguera & Kevin D. McCarthy & Teena Mehta & Julie S. Nicoll & Mark T. Tuominen & Derek R. Lovley, 2005. "Extracellular electron transfer via microbial nanowires," Nature, Nature, vol. 435(7045), pages 1098-1101, June.
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    Cited by:

    1. Yanli Huang & Xufeng Wan & Qiang Su & Chunlin Zhao & Jian Cao & Yan Yue & Shuoyuan Li & Xiaoting Chen & Jie Yin & Yi Deng & Xianzeng Zhang & Tianmin Wu & Zongke Zhou & Duan Wang, 2024. "Ultrasound-activated piezo-hot carriers trigger tandem catalysis coordinating cuproptosis-like bacterial death against implant infections," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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