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Listeria monocytogenes faecal carriage is common and depends on the gut microbiota

Author

Listed:
  • Lukas Hafner

    (Institut Pasteur, Université de Paris, Inserm U1117, Biology of Infection Unit)

  • Maxime Pichon

    (University Hospital of Poitiers, Infectious Agents Department, Bacteriology and Infection Control Laboratory
    Université de Poitiers, Faculté de Médecine et de Pharmacie
    Université de Poitiers, Faculté de Médecine et de Pharmacie)

  • Christophe Burucoa

    (University Hospital of Poitiers, Infectious Agents Department, Bacteriology and Infection Control Laboratory
    Université de Poitiers, Faculté de Médecine et de Pharmacie
    Université de Poitiers, Faculté de Médecine et de Pharmacie)

  • Sophie H. A. Nusser

    (Institut Pasteur, Université de Paris, Inserm U1117, Biology of Infection Unit)

  • Alexandra Moura

    (Institut Pasteur, Université de Paris, Inserm U1117, Biology of Infection Unit
    Institut Pasteur, National Reference Center and WHO Collaborating Center Listeria)

  • Marc Garcia-Garcera

    (University of Lausanne, Department of Fundamental Microbiology)

  • Marc Lecuit

    (Institut Pasteur, Université de Paris, Inserm U1117, Biology of Infection Unit
    Institut Pasteur, National Reference Center and WHO Collaborating Center Listeria
    Necker-Enfants Malades University Hospital, Division of Infectious Diseases and Tropical Medicine, APHP, Institut Imagine)

Abstract

Listeria genus comprises two pathogenic species, L. monocytogenes (Lm) and L. ivanovii, and non-pathogenic species. All can thrive as saprophytes, whereas only pathogenic species cause systemic infections. Identifying Listeria species’ respective biotopes is critical to understand the ecological contribution of Listeria virulence. In order to investigate the prevalence and abundance of Listeria species in various sources, we retrieved and analyzed 16S rRNA datasets from MG-RAST metagenomic database. 26% of datasets contain Listeria sensu stricto sequences, and Lm is the most prevalent species, most abundant in soil and host-associated environments, including 5% of human stools. Lm is also detected in 10% of human stool samples from an independent cohort of 900 healthy asymptomatic donors. A specific microbiota signature is associated with Lm faecal carriage, both in humans and experimentally inoculated mice, in which it precedes Lm faecal carriage. These results indicate that Lm faecal carriage is common and depends on the gut microbiota, and suggest that Lm faecal carriage is a crucial yet overlooked consequence of its virulence.

Suggested Citation

  • Lukas Hafner & Maxime Pichon & Christophe Burucoa & Sophie H. A. Nusser & Alexandra Moura & Marc Garcia-Garcera & Marc Lecuit, 2021. "Listeria monocytogenes faecal carriage is common and depends on the gut microbiota," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27069-y
    DOI: 10.1038/s41467-021-27069-y
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    References listed on IDEAS

    as
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    2. Mylène M. Maury & Hélène Bracq-Dieye & Lei Huang & Guillaume Vales & Morgane Lavina & Pierre Thouvenot & Olivier Disson & Alexandre Leclercq & Sylvain Brisse & Marc Lecuit, 2019. "Hypervirulent Listeria monocytogenes clones’ adaption to mammalian gut accounts for their association with dairy products," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    3. Alejandro Toledo-Arana & Olivier Dussurget & Georgios Nikitas & Nina Sesto & Hélène Guet-Revillet & Damien Balestrino & Edmund Loh & Jonas Gripenland & Teresa Tiensuu & Karolis Vaitkevicius & Mathieu , 2009. "The Listeria transcriptional landscape from saprophytism to virulence," Nature, Nature, vol. 459(7249), pages 950-956, June.
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