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The Listeria transcriptional landscape from saprophytism to virulence

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  • Alejandro Toledo-Arana

    (Institut Pasteur, Unité des Interactions Bactéries-Cellules
    Inserm, U604, F-75015 Paris, France
    INRA, USC2020, F-75015 Paris, France
    Present address: Instituto de Agrobiotecnología, Universidad Pública de Navarra-CSIC-Gobierno de Navarra, 31006-Pamplona, Spain.)

  • Olivier Dussurget

    (Institut Pasteur, Unité des Interactions Bactéries-Cellules
    Inserm, U604, F-75015 Paris, France
    INRA, USC2020, F-75015 Paris, France)

  • Georgios Nikitas

    (Inserm, U604, F-75015 Paris, France
    Institut Pasteur, G5 Microorganismes et Barrières de l’hôte, F-75015 Paris, France
    Inserm, Avenir, U604, F-75015 Paris, France)

  • Nina Sesto

    (Institut Pasteur, Unité des Interactions Bactéries-Cellules
    Inserm, U604, F-75015 Paris, France
    INRA, USC2020, F-75015 Paris, France)

  • Hélène Guet-Revillet

    (Institut Pasteur, Unité des Interactions Bactéries-Cellules
    Inserm, U604, F-75015 Paris, France
    INRA, USC2020, F-75015 Paris, France)

  • Damien Balestrino

    (Institut Pasteur, Unité des Interactions Bactéries-Cellules
    Inserm, U604, F-75015 Paris, France
    INRA, USC2020, F-75015 Paris, France)

  • Edmund Loh

    (Department of Molecular Biology,
    The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, S-90187 Umeå, Sweden)

  • Jonas Gripenland

    (Department of Molecular Biology,
    The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, S-90187 Umeå, Sweden)

  • Teresa Tiensuu

    (Department of Molecular Biology,
    The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, S-90187 Umeå, Sweden)

  • Karolis Vaitkevicius

    (Department of Molecular Biology,
    The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, S-90187 Umeå, Sweden)

  • Mathieu Barthelemy

    (Institut Pasteur, Génopole, Plate-forme 2, F-75015 Paris, France)

  • Massimo Vergassola

    (Institut Pasteur, UP Génétique in silico, F-75015 Paris, France
    CNRS, URA2171, F-75015 Paris, France)

  • Marie-Anne Nahori

    (Institut Pasteur, Unité des Interactions Bactéries-Cellules
    Inserm, U604, F-75015 Paris, France
    INRA, USC2020, F-75015 Paris, France)

  • Guillaume Soubigou

    (Institut Pasteur, Génopole, Plate-forme 2, F-75015 Paris, France)

  • Béatrice Régnault

    (Institut Pasteur, Génopole, Plate-forme 2, F-75015 Paris, France)

  • Jean-Yves Coppée

    (Institut Pasteur, Génopole, Plate-forme 2, F-75015 Paris, France)

  • Marc Lecuit

    (Inserm, U604, F-75015 Paris, France
    Institut Pasteur, G5 Microorganismes et Barrières de l’hôte, F-75015 Paris, France
    Inserm, Avenir, U604, F-75015 Paris, France
    Université Paris Descartes, Hôpital Necker-Enfants malades, Assistance Publique-Hôpitaux de Paris, Paris, F-75015 France)

  • Jörgen Johansson

    (Department of Molecular Biology,
    The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, S-90187 Umeå, Sweden)

  • Pascale Cossart

    (Institut Pasteur, Unité des Interactions Bactéries-Cellules
    Inserm, U604, F-75015 Paris, France
    INRA, USC2020, F-75015 Paris, France)

Abstract

The bacterium Listeria monocytogenes is ubiquitous in the environment and can lead to severe food-borne infections. It has recently emerged as a multifaceted model in pathogenesis. However, how this bacterium switches from a saprophyte to a pathogen is largely unknown. Here, using tiling arrays and RNAs from wild-type and mutant bacteria grown in vitro, ex vivo and in vivo, we have analysed the transcription of its entire genome. We provide the complete Listeria operon map and have uncovered far more diverse types of RNAs than expected: in addition to 50 small RNAs (

Suggested Citation

  • Alejandro Toledo-Arana & Olivier Dussurget & Georgios Nikitas & Nina Sesto & Hélène Guet-Revillet & Damien Balestrino & Edmund Loh & Jonas Gripenland & Teresa Tiensuu & Karolis Vaitkevicius & Mathieu , 2009. "The Listeria transcriptional landscape from saprophytism to virulence," Nature, Nature, vol. 459(7249), pages 950-956, June.
    • Handle: RePEc:nat:nature:v:459:y:2009:i:7249:d:10.1038_nature08080
    DOI: 10.1038/nature08080
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    Cited by:

    1. Rupert L. Mayer & Rein Verbeke & Caroline Asselman & Ilke Aernout & Adillah Gul & Denzel Eggermont & Katie Boucher & Fabien Thery & Teresa M. Maia & Hans Demol & Ralf Gabriels & Lennart Martens & Chri, 2022. "Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Lukas Hafner & Maxime Pichon & Christophe Burucoa & Sophie H. A. Nusser & Alexandra Moura & Marc Garcia-Garcera & Marc Lecuit, 2021. "Listeria monocytogenes faecal carriage is common and depends on the gut microbiota," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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