Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction
Author
Abstract
Suggested Citation
DOI: 10.1038/s41467-021-26844-1
Download full text from publisher
References listed on IDEAS
- Norihiko Watanabe & Yi-Hong Wang & Heung Kyu Lee & Tomoki Ito & Yui-Hsi Wang & Wei Cao & Yong-Jun Liu, 2005. "Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus," Nature, Nature, vol. 436(7054), pages 1181-1185, August.
- Tao Xu & Kelly M. Stewart & Xiaohu Wang & Kai Liu & Min Xie & Jae Kyu Ryu & Ke Li & Tianhua Ma & Haixia Wang & Lu Ni & Saiyong Zhu & Nan Cao & Dongwei Zhu & Yu Zhang & Katerina Akassoglou & Chen Dong , 2017. "Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism," Nature, Nature, vol. 548(7666), pages 228-233, August.
- Hu Zeng & Kai Yang & Caryn Cloer & Geoffrey Neale & Peter Vogel & Hongbo Chi, 2013. "mTORC1 couples immune signals and metabolic programming to establish Treg-cell function," Nature, Nature, vol. 499(7459), pages 485-490, July.
Most related items
These are the items that most often cite the same works as this one and are cited by the same works as this one.- Christophe M. Capelle & Séverine Ciré & Fanny Hedin & Maxime Hansen & Lukas Pavelka & Kamil Grzyb & Dimitrios Kyriakis & Oliver Hunewald & Maria Konstantinou & Dominique Revets & Vera Tslaf & Tainá M., 2023. "Early-to-mid stage idiopathic Parkinson’s disease shows enhanced cytotoxicity and differentiation in CD8 T-cells in females," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
- Kuniyuki Aso & Michihito Kono & Masatoshi Kanda & Yuki Kudo & Kodai Sakiyama & Ryo Hisada & Kohei Karino & Yusho Ueda & Daigo Nakazawa & Yuichiro Fujieda & Masaru Kato & Olga Amengual & Tatsuya Atsumi, 2023. "Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
- Niranjana Natarajan & Jonathan Florentin & Ebin Johny & Hanxi Xiao & Scott Patrick O’Neil & Liqun Lei & Jixing Shen & Lee Ohayon & Aaron R. Johnson & Krithika Rao & Xiaoyun Li & Yanwu Zhao & Yingze Zh, 2024. "Aberrant mitochondrial DNA synthesis in macrophages exacerbates inflammation and atherosclerosis," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
- Seymour Picciotto & Nicholas DeVita & Chiaowen Joyce Hsiao & Christopher Honan & Sze-Wah Tse & Mychael Nguyen & Joseph D. Ferrari & Wei Zheng & Brian T. Wipke & Eric Huang, 2022. "Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
- Di Wu & Haomin Li & Mingwei Liu & Jun Qin & Yi Sun, 2022. "The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
- Xinyu Mei & Yuan Guo & Zhangdan Xie & Yedan Zhong & Xiaofen Wu & Daichao Xu & Ying Li & Nan Liu & Zheng-Jiang Zhu, 2021. "RIPK1 regulates starvation resistance by modulating aspartate catabolism," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
- Viviana Volta & Sandra Pérez-Baos & Columba Parra & Olga Katsara & Amanda Ernlund & Sophie Dornbaum & Robert J. Schneider, 2021. "A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26844-1. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through the various RePEc services.