IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v499y2013i7459d10.1038_nature12297.html
   My bibliography  Save this article

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

Author

Listed:
  • Hu Zeng

    (St Jude Children’s Research Hospital)

  • Kai Yang

    (St Jude Children’s Research Hospital)

  • Caryn Cloer

    (St Jude Children’s Research Hospital)

  • Geoffrey Neale

    (Hartwell Center for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital)

  • Peter Vogel

    (St Jude Children’s Research Hospital)

  • Hongbo Chi

    (St Jude Children’s Research Hospital)

Abstract

Here, mTORC1-dependent lipogenic programming is shown to be important for regulatory T-cell function, in part through the upregulation of the effector molecules CTLA4 and ICOS.

Suggested Citation

  • Hu Zeng & Kai Yang & Caryn Cloer & Geoffrey Neale & Peter Vogel & Hongbo Chi, 2013. "mTORC1 couples immune signals and metabolic programming to establish Treg-cell function," Nature, Nature, vol. 499(7459), pages 485-490, July.
    • Handle: RePEc:nat:nature:v:499:y:2013:i:7459:d:10.1038_nature12297
    DOI: 10.1038/nature12297
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12297
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12297?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Di Wu & Haomin Li & Mingwei Liu & Jun Qin & Yi Sun, 2022. "The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Viviana Volta & Sandra Pérez-Baos & Columba Parra & Olga Katsara & Amanda Ernlund & Sophie Dornbaum & Robert J. Schneider, 2021. "A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    3. Baptiste Lamarthée & Armance Marchal & Soëli Charbonnier & Tifanie Blein & Juliette Leon & Emmanuel Martin & Lucas Rabaux & Katrin Vogt & Matthias Titeux & Marianne Delville & Hélène Vinçon & Emmanuel, 2021. "Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    4. Christophe M. Capelle & Séverine Ciré & Fanny Hedin & Maxime Hansen & Lukas Pavelka & Kamil Grzyb & Dimitrios Kyriakis & Oliver Hunewald & Maria Konstantinou & Dominique Revets & Vera Tslaf & Tainá M., 2023. "Early-to-mid stage idiopathic Parkinson’s disease shows enhanced cytotoxicity and differentiation in CD8 T-cells in females," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    5. Seymour Picciotto & Nicholas DeVita & Chiaowen Joyce Hsiao & Christopher Honan & Sze-Wah Tse & Mychael Nguyen & Joseph D. Ferrari & Wei Zheng & Brian T. Wipke & Eric Huang, 2022. "Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:499:y:2013:i:7459:d:10.1038_nature12297. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.