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Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism

Author

Listed:
  • Tao Xu

    (The J. David Gladstone Institutes)

  • Kelly M. Stewart

    (Agios Pharmaceuticals)

  • Xiaohu Wang

    (Institute for Immunology and School of Medicine, Tsinghua University)

  • Kai Liu

    (The J. David Gladstone Institutes)

  • Min Xie

    (The J. David Gladstone Institutes)

  • Jae Kyu Ryu

    (The J. David Gladstone Institutes)

  • Ke Li

    (The J. David Gladstone Institutes)

  • Tianhua Ma

    (The J. David Gladstone Institutes
    School of Pharmaceutical Sciences, Tsinghua University)

  • Haixia Wang

    (The J. David Gladstone Institutes)

  • Lu Ni

    (Institute for Immunology and School of Medicine, Tsinghua University)

  • Saiyong Zhu

    (The J. David Gladstone Institutes)

  • Nan Cao

    (The J. David Gladstone Institutes)

  • Dongwei Zhu

    (Agios Pharmaceuticals)

  • Yu Zhang

    (The J. David Gladstone Institutes)

  • Katerina Akassoglou

    (The J. David Gladstone Institutes
    University of California, San Francisco, San Francisco)

  • Chen Dong

    (Institute for Immunology and School of Medicine, Tsinghua University)

  • Edward M. Driggers

    (Agios Pharmaceuticals
    General Metabolics, LLC)

  • Sheng Ding

    (The J. David Gladstone Institutes
    School of Pharmaceutical Sciences, Tsinghua University)

Abstract

Metabolic changes in T cells can affect the genomic methylation status of key transcription factors and regulate the fate decision between induced regulatory T cells and T helper 17 cells.

Suggested Citation

  • Tao Xu & Kelly M. Stewart & Xiaohu Wang & Kai Liu & Min Xie & Jae Kyu Ryu & Ke Li & Tianhua Ma & Haixia Wang & Lu Ni & Saiyong Zhu & Nan Cao & Dongwei Zhu & Yu Zhang & Katerina Akassoglou & Chen Dong , 2017. "Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism," Nature, Nature, vol. 548(7666), pages 228-233, August.
    • Handle: RePEc:nat:nature:v:548:y:2017:i:7666:d:10.1038_nature23475
    DOI: 10.1038/nature23475
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    Cited by:

    1. Baptiste Lamarthée & Armance Marchal & Soëli Charbonnier & Tifanie Blein & Juliette Leon & Emmanuel Martin & Lucas Rabaux & Katrin Vogt & Matthias Titeux & Marianne Delville & Hélène Vinçon & Emmanuel, 2021. "Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    2. Kuniyuki Aso & Michihito Kono & Masatoshi Kanda & Yuki Kudo & Kodai Sakiyama & Ryo Hisada & Kohei Karino & Yusho Ueda & Daigo Nakazawa & Yuichiro Fujieda & Masaru Kato & Olga Amengual & Tatsuya Atsumi, 2023. "Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Xinyu Mei & Yuan Guo & Zhangdan Xie & Yedan Zhong & Xiaofen Wu & Daichao Xu & Ying Li & Nan Liu & Zheng-Jiang Zhu, 2021. "RIPK1 regulates starvation resistance by modulating aspartate catabolism," Nature Communications, Nature, vol. 12(1), pages 1-16, December.

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