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Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Author

Listed:
  • Chuanyan Wu

    (Lund University
    School of Control Science and Engineering, Shandong University
    School of Intelligent Engineering, Shandong Management University)

  • Yan Borné

    (Lund University)

  • Rui Gao

    (School of Control Science and Engineering, Shandong University)

  • Maykel López Rodriguez

    (Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
    University of Eastern Finland)

  • William C. Roell

    (Lilly Research Laboratories, Eli Lilly and Company)

  • Jonathan M. Wilson

    (Lilly Research Laboratories, Eli Lilly and Company)

  • Ajit Regmi

    (Lilly Research Laboratories, Eli Lilly and Company)

  • Cheng Luan

    (Lund University)

  • Dina Mansour Aly

    (Lund University)

  • Andreas Peter

    (Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tübingen, University of Tübingen
    Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich
    German Center for Diabetes Research (DZD))

  • Jürgen Machann

    (Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich
    German Center for Diabetes Research (DZD)
    University of Tübingen)

  • Harald Staiger

    (Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tübingen, University of Tübingen
    Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich
    German Center for Diabetes Research (DZD))

  • Andreas Fritsche

    (Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tübingen, University of Tübingen
    Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich
    German Center for Diabetes Research (DZD))

  • Andreas L. Birkenfeld

    (Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tübingen, University of Tübingen
    Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich
    German Center for Diabetes Research (DZD))

  • Rongya Tao

    (Boston Children’s Hospital, Harvard Medical School)

  • Robert Wagner

    (Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tübingen, University of Tübingen
    Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich
    German Center for Diabetes Research (DZD))

  • Mickaël Canouil

    (Inserm U1283 / CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille; University of Lille, Lille University Hospital)

  • Mun-Gwan Hong

    (Affinity Proteomics, Science for Life Laboratory, KTH Royal Institute of Technology)

  • Jochen M. Schwenk

    (Affinity Proteomics, Science for Life Laboratory, KTH Royal Institute of Technology)

  • Emma Ahlqvist

    (Lund University)

  • Minna U. Kaikkonen

    (University of Eastern Finland)

  • Peter Nilsson

    (Lund University)

  • Angela C. Shore

    (NIHR Exeter Clinical Research Facility, Royal Devon and Exeter Hospital and University of Exeter Medical School, Exeter)

  • Faisel Khan

    (University of Dundee, Ninewells Hospital & Medical School)

  • Andrea Natali

    (University of Pisa)

  • Olle Melander

    (Lund University)

  • Marju Orho-Melander

    (Lund University)

  • Jan Nilsson

    (Lund University)

  • Hans-Ulrich Häring

    (Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tübingen, University of Tübingen
    Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich
    German Center for Diabetes Research (DZD))

  • Erik Renström

    (Lund University)

  • Claes B. Wollheim

    (Lund University
    University Medical Centre)

  • Gunnar Engström

    (Lund University)

  • Jianping Weng

    (University of Science and Technology of China)

  • Ewan R. Pearson

    (School of Medicine, University of Dundee)

  • Paul W. Franks

    (Lund University)

  • Morris F. White

    (Boston Children’s Hospital, Harvard Medical School)

  • Kevin L. Duffin

    (Lilly Research Laboratories, Eli Lilly and Company)

  • Allan Arthur Vaag

    (Steno Diabetes Center Copenhagen)

  • Markku Laakso

    (Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
    Kuopio University Hospital)

  • Norbert Stefan

    (Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tübingen, University of Tübingen
    Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich
    German Center for Diabetes Research (DZD))

  • Leif Groop

    (Lund University
    Finnish Institute for Molecular Medicine, University of Helsinki)

  • Yang De Marinis

    (Lund University
    School of Control Science and Engineering, Shandong University
    University of Science and Technology of China)

Abstract

The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with incident T2D and mechanisms involved. Adjusted hazard ratio (HR) per standard deviation (SD) increase in follistatin levels for T2D is 1.24 (CI: 1.04–1.47, p

Suggested Citation

  • Chuanyan Wu & Yan Borné & Rui Gao & Maykel López Rodriguez & William C. Roell & Jonathan M. Wilson & Ajit Regmi & Cheng Luan & Dina Mansour Aly & Andreas Peter & Jürgen Machann & Harald Staiger & Andr, 2021. "Elevated circulating follistatin associates with an increased risk of type 2 diabetes," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26536-w
    DOI: 10.1038/s41467-021-26536-w
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    References listed on IDEAS

    as
    1. Alexandra C. McPherron & Ann M. Lawler & Se-Jin Lee, 1997. "Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member," Nature, Nature, vol. 387(6628), pages 83-90, May.
    2. David J. Lloyd & David J. St Jean & Robert J. M. Kurzeja & Robert C. Wahl & Klaus Michelsen & Rod Cupples & Michelle Chen & John Wu & Glenn Sivits & Joan Helmering & Renée Komorowski & Kate S. Ashton , 2013. "Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors," Nature, Nature, vol. 504(7480), pages 437-440, December.
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    Cited by:

    1. Parsa Akbari & Olukayode A. Sosina & Jonas Bovijn & Karl Landheer & Jonas B. Nielsen & Minhee Kim & Senem Aykul & Tanima De & Mary E. Haas & George Hindy & Nan Lin & Ian R. Dinsmore & Jonathan Z. Luo , 2022. "Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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