IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i13p4900-d381430.html
   My bibliography  Save this article

Myostatin A55T Genotype is Associated with Strength Recovery Following Exercise-Induced Muscle Damage

Author

Listed:
  • Jooyoung Kim

    (Office of Academic Affairs, Konkuk University, Chungju-si 27478, Korea)

  • Kwanghoon Park

    (Department of Sport, Health and Rehabilitation, College of Physical Education, Kookmin University, Seoul 02707, Korea)

  • Joohyung Lee

    (Department of Sport, Health and Rehabilitation, College of Physical Education, Kookmin University, Seoul 02707, Korea)

Abstract

Myostatin A55T genotype is one of the candidates showing inter-individual variation in skeletal muscle phenotypes. The aim of this study was to investigate the effect of the myostatin A55T genotype on markers of muscle damage after eccentric exercise. Forty-eight young, healthy male college students (age = 24.8 ± 2.2 years, height = 176.7 ± 5.3 cm, weight = 73.7 ± 8.3 kg) were enrolled in this study, and muscle damage was induced through 50 reps of maximal eccentric muscle contraction. As markers of muscle damage, maximal isometric strength (MIS), muscle soreness, creatine kinase (CK), and aspartate transaminase (AST) were measured. Myostatin A55T genotypes were classified into homozygous myostatin A55T allele (AA, n = 34, 72%), heterozygous myostatin A55T allele (AT, n = 13, 26%), and homozygous mutant carriers (TT, n = 1, 2%). After eccentric exercise, the subjects with heterozygous for AT showed markedly quicker MIS recovery compared to the AA group ( p = 0.042). However, there were no significant variations in muscle soreness ( p = 0.379), CK ( p = 0.955), and AST ( p = 0.706) among the groups. These results suggest that AT in myostatin A55T genotype may be associated with quicker strength recovery following exercise-induced muscle damage.

Suggested Citation

  • Jooyoung Kim & Kwanghoon Park & Joohyung Lee, 2020. "Myostatin A55T Genotype is Associated with Strength Recovery Following Exercise-Induced Muscle Damage," IJERPH, MDPI, vol. 17(13), pages 1-8, July.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:13:p:4900-:d:381430
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/13/4900/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/13/4900/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Alexandra C. McPherron & Ann M. Lawler & Se-Jin Lee, 1997. "Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member," Nature, Nature, vol. 387(6628), pages 83-90, May.
    2. Jooyoung Kim & Joohyung Lee, 2020. "Plasma MMP-9, TIMP-1, and TGF-β1 Responses to Exercise-Induced Muscle Injury," IJERPH, MDPI, vol. 17(2), pages 1-12, January.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. X.P. An & J.G. Wang & J.X. Hou & H.B. Zhao & L. Bai & G. Li & L.X. Wang & X.Q. Liu & W.P. Xiao & Y.X. Song & B.Y. Cao, 2011. "Polymorphism identification in the goat MSTN gene and association analysis with growth traits," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 56(12), pages 529-535.
    2. Chuanyan Wu & Yan Borné & Rui Gao & Maykel López Rodriguez & William C. Roell & Jonathan M. Wilson & Ajit Regmi & Cheng Luan & Dina Mansour Aly & Andreas Peter & Jürgen Machann & Harald Staiger & Andr, 2021. "Elevated circulating follistatin associates with an increased risk of type 2 diabetes," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    3. Remigiusz Domin & Daniela Dadej & Michał Pytka & Ariadna Zybek-Kocik & Marek Ruchała & Przemysław Guzik, 2021. "Effect of Various Exercise Regimens on Selected Exercise-Induced Cytokines in Healthy People," IJERPH, MDPI, vol. 18(3), pages 1-36, January.
    4. Hanfang Bi & Shanshan Xie & Chunbo Cai & Lili Qian & Shengwang Jiang & Gaojun Xiao & Biao Li & Xiang Li & Wentao Cui, 2020. "Frameshift mutation in myostatin gene by zinc-finger nucleases results in a significant increase in muscle mass in Meishan sows," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 65(5), pages 182-191.
    5. Jennifer M. Petrosino & Scott A. Hinger & Volha A. Golubeva & Juan M. Barajas & Lisa E. Dorn & Chitra C. Iyer & Hui-Lung Sun & W. David Arnold & Chuan He & Federica Accornero, 2022. "The m6A methyltransferase METTL3 regulates muscle maintenance and growth in mice," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    6. Marco Thürkauf & Shuo Lin & Filippo Oliveri & Dirk Grimm & Randall J. Platt & Markus A. Rüegg, 2023. "Fast, multiplexable and efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    7. Katsuhiko Suzuki & Amir Hossein Ahmadi Hekmatikar & Shadi Jalalian & Shaghayegh Abbasi & Elmira Ahmadi & Abdolreza Kazemi & Ruheea Taskin Ruhee & Kayvan Khoramipour, 2022. "The Potential of Exerkines in Women’s COVID-19: A New Idea for a Better and More Accurate Understanding of the Mechanisms behind Physical Exercise," IJERPH, MDPI, vol. 19(23), pages 1-21, November.
    8. Flavia A. Graca & Mamta Rai & Liam C. Hunt & Anna Stephan & Yong-Dong Wang & Brittney Gordon & Ruishan Wang & Giovanni Quarato & Beisi Xu & Yiping Fan & Myriam Labelle & Fabio Demontis, 2022. "The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:13:p:4900-:d:381430. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.