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Addressing MRSA infection and antibacterial resistance with peptoid polymers

Author

Listed:
  • Jiayang Xie

    (East China University of Science and Technology)

  • Min Zhou

    (East China University of Science and Technology)

  • Yuxin Qian

    (East China University of Science and Technology)

  • Zihao Cong

    (East China University of Science and Technology)

  • Sheng Chen

    (East China University of Science and Technology)

  • Wenjing Zhang

    (East China University of Science and Technology)

  • Weinan Jiang

    (East China University of Science and Technology)

  • Chengzhi Dai

    (East China University of Science and Technology)

  • Ning Shao

    (East China University of Science and Technology)

  • Zhemin Ji

    (East China University of Science and Technology)

  • Jingcheng Zou

    (East China University of Science and Technology)

  • Ximian Xiao

    (East China University of Science and Technology)

  • Longqiang Liu

    (East China University of Science and Technology)

  • Minzhang Chen

    (East China University of Science and Technology)

  • Jin Li

    (Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine)

  • Runhui Liu

    (East China University of Science and Technology
    East China University of Science and Technology)

Abstract

Methicillin-Resistant Staphylococcus aureus (MRSA) induced infection calls for antibacterial agents that are not prone to antimicrobial resistance. We prepare protease-resistant peptoid polymers with variable C-terminal functional groups using a ring-opening polymerization of N-substituted N-carboxyanhydrides (NNCA), which can provide peptoid polymers easily from the one-pot synthesis. We study the optimal polymer that displays effective activity against MRSA planktonic and persister cells, effective eradication of highly antibiotic-resistant MRSA biofilms, and potent anti-infectious performance in vivo using the wound infection model, the mouse keratitis model, and the mouse peritonitis model. Peptoid polymers show insusceptibility to antimicrobial resistance, which is a prominent merit of these antimicrobial agents. The low cost, convenient synthesis and structure diversity of peptoid polymers, the superior antimicrobial performance and therapeutic potential in treating MRSA infection altogether imply great potential of peptoid polymers as promising antibacterial agents in treating MRSA infection and alleviating antibiotic resistance.

Suggested Citation

  • Jiayang Xie & Min Zhou & Yuxin Qian & Zihao Cong & Sheng Chen & Wenjing Zhang & Weinan Jiang & Chengzhi Dai & Ning Shao & Zhemin Ji & Jingcheng Zou & Ximian Xiao & Longqiang Liu & Minzhang Chen & Jin , 2021. "Addressing MRSA infection and antibacterial resistance with peptoid polymers," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26221-y
    DOI: 10.1038/s41467-021-26221-y
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    References listed on IDEAS

    as
    1. Yueming Wu & Danfeng Zhang & Pengcheng Ma & Ruiyi Zhou & Lei Hua & Runhui Liu, 2018. "Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    2. Kazuki Fukushima & Shaoqiong Liu & Hong Wu & Amanda C. Engler & Daniel J. Coady & Hareem Maune & Jed Pitera & Alshakim Nelson & Nikken Wiradharma & Shrinivas Venkataraman & Yuan Huang & Weimin Fan & J, 2013. "Supramolecular high-aspect ratio assemblies with strong antifungal activity," Nature Communications, Nature, vol. 4(1), pages 1-9, December.
    3. Ernest Y. Lee & Changsheng Zhang & Jeremy Di Domizio & Fan Jin & Will Connell & Mandy Hung & Nicolas Malkoff & Veronica Veksler & Michel Gilliet & Pengyu Ren & Gerard C. L. Wong, 2019. "Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    4. Michael Zasloff, 2002. "Antimicrobial peptides of multicellular organisms," Nature, Nature, vol. 415(6870), pages 389-395, January.
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    Cited by:

    1. Tianyu Wu & Min Zhou & Jingcheng Zou & Qi Chen & Feng Qian & Jürgen Kurths & Runhui Liu & Yang Tang, 2024. "AI-guided few-shot inverse design of HDP-mimicking polymers against drug-resistant bacteria," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    2. Jian Cheng & Guihai Gan & Shaoqiu Zheng & Guoying Zhang & Chen Zhu & Shiyong Liu & Jinming Hu, 2023. "Biofilm heterogeneity-adaptive photoredox catalysis enables red light-triggered nitric oxide release for combating drug-resistant infections," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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