IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-17280-8.html
   My bibliography  Save this article

Early triage of critically ill COVID-19 patients using deep learning

Author

Listed:
  • Wenhua Liang

    (The First Affiliated Hospital of Guangzhou Medical University)

  • Jianhua Yao

    (Tencent AI Lab)

  • Ailan Chen

    (The First Affiliated Hospital of Guangzhou Medical University
    Hankou Hospital)

  • Qingquan Lv

    (Hankou Hospital)

  • Mark Zanin

    (The University of Hong Kong)

  • Jun Liu

    (The First Affiliated Hospital of Guangzhou Medical University
    The First Affiliated Hospital of Guangzhou Medical University)

  • SookSan Wong

    (The First Affiliated Hospital of Guangzhou Medical University)

  • Yimin Li

    (The First Affiliated Hospital of Guangzhou Medical University)

  • Jiatao Lu

    (Hankou Hospital)

  • Hengrui Liang

    (The First Affiliated Hospital of Guangzhou Medical University
    The First Affiliated Hospital of Guangzhou Medical University)

  • Guoqiang Chen

    (Foshan Hospital)

  • Haiyan Guo

    (Foshan Hospital)

  • Jun Guo

    (Daye Hospital)

  • Rong Zhou

    (The First Affiliated Hospital of Guangzhou Medical University)

  • Limin Ou

    (The First Affiliated Hospital of Guangzhou Medical University)

  • Niyun Zhou

    (Tencent AI Lab)

  • Hanbo Chen

    (Tencent AI Lab)

  • Fan Yang

    (Tencent AI Lab)

  • Xiao Han

    (Tencent AI Lab)

  • Wenjing Huan

    (Tencent Healthcare)

  • Weimin Tang

    (Tencent Healthcare)

  • Weijie Guan

    (The First Affiliated Hospital of Guangzhou Medical University)

  • Zisheng Chen

    (The First Affiliated Hospital of Guangzhou Medical University
    The Sixth Affiliated Hospital of Guangzhou Medical University)

  • Yi Zhao

    (The First Affiliated Hospital of Guangzhou Medical University)

  • Ling Sang

    (The First Affiliated Hospital of Guangzhou Medical University)

  • Yuanda Xu

    (The First Affiliated Hospital of Guangzhou Medical University)

  • Wei Wang

    (The First Affiliated Hospital of Guangzhou Medical University)

  • Shiyue Li

    (The First Affiliated Hospital of Guangzhou Medical University)

  • Ligong Lu

    (Zhuhai People Hospital)

  • Nuofu Zhang

    (The First Affiliated Hospital of Guangzhou Medical University)

  • Nanshan Zhong

    (The First Affiliated Hospital of Guangzhou Medical University)

  • Junzhou Huang

    (Tencent AI Lab)

  • Jianxing He

    (The First Affiliated Hospital of Guangzhou Medical University)

Abstract

The sudden deterioration of patients with novel coronavirus disease 2019 (COVID-19) into critical illness is of major concern. It is imperative to identify these patients early. We show that a deep learning-based survival model can predict the risk of COVID-19 patients developing critical illness based on clinical characteristics at admission. We develop this model using a cohort of 1590 patients from 575 medical centers, with internal validation performance of concordance index 0.894 We further validate the model on three separate cohorts from Wuhan, Hubei and Guangdong provinces consisting of 1393 patients with concordance indexes of 0.890, 0.852 and 0.967 respectively. This model is used to create an online calculation tool designed for patient triage at admission to identify patients at risk of severe illness, ensuring that patients at greatest risk of severe illness receive appropriate care as early as possible and allow for effective allocation of health resources.

Suggested Citation

  • Wenhua Liang & Jianhua Yao & Ailan Chen & Qingquan Lv & Mark Zanin & Jun Liu & SookSan Wong & Yimin Li & Jiatao Lu & Hengrui Liang & Guoqiang Chen & Haiyan Guo & Jun Guo & Rong Zhou & Limin Ou & Niyun, 2020. "Early triage of critically ill COVID-19 patients using deep learning," Nature Communications, Nature, vol. 11(1), pages 1-7, December.
  • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17280-8
    DOI: 10.1038/s41467-020-17280-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-17280-8
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-020-17280-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. van Buuren, Stef & Groothuis-Oudshoorn, Karin, 2011. "mice: Multivariate Imputation by Chained Equations in R," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 45(i03).
    2. Simon, Noah & Friedman, Jerome H. & Hastie, Trevor & Tibshirani, Rob, 2011. "Regularization Paths for Cox's Proportional Hazards Model via Coordinate Descent," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 39(i05).
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Longling Zhang & Bochen Shen & Ahmed Barnawi & Shan Xi & Neeraj Kumar & Yi Wu, 2021. "FedDPGAN: Federated Differentially Private Generative Adversarial Networks Framework for the Detection of COVID-19 Pneumonia," Information Systems Frontiers, Springer, vol. 23(6), pages 1403-1415, December.
    2. Francesco Piccialli & Vincenzo Schiano Cola & Fabio Giampaolo & Salvatore Cuomo, 2021. "The Role of Artificial Intelligence in Fighting the COVID-19 Pandemic," Information Systems Frontiers, Springer, vol. 23(6), pages 1467-1497, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Andreas Groll & Gerhard Tutz, 2017. "Variable selection in discrete survival models including heterogeneity," Lifetime Data Analysis: An International Journal Devoted to Statistical Methods and Applications for Time-to-Event Data, Springer, vol. 23(2), pages 305-338, April.
    2. Abhilash Bandam & Eedris Busari & Chloi Syranidou & Jochen Linssen & Detlef Stolten, 2022. "Classification of Building Types in Germany: A Data-Driven Modeling Approach," Data, MDPI, vol. 7(4), pages 1-23, April.
    3. Boonstra Philip S. & Little Roderick J.A. & West Brady T. & Andridge Rebecca R. & Alvarado-Leiton Fernanda, 2021. "A Simulation Study of Diagnostics for Selection Bias," Journal of Official Statistics, Sciendo, vol. 37(3), pages 751-769, September.
    4. Christopher J Greenwood & George J Youssef & Primrose Letcher & Jacqui A Macdonald & Lauryn J Hagg & Ann Sanson & Jenn Mcintosh & Delyse M Hutchinson & John W Toumbourou & Matthew Fuller-Tyszkiewicz &, 2020. "A comparison of penalised regression methods for informing the selection of predictive markers," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-14, November.
    5. Norah Alyabs & Sy Han Chiou, 2022. "The Missing Indicator Approach for Accelerated Failure Time Model with Covariates Subject to Limits of Detection," Stats, MDPI, vol. 5(2), pages 1-13, May.
    6. Soave, David & Lawless, Jerald F., 2023. "Regularized regression for two phase failure time studies," Computational Statistics & Data Analysis, Elsevier, vol. 182(C).
    7. Eunsil Seok & Akhgar Ghassabian & Yuyan Wang & Mengling Liu, 2024. "Statistical Methods for Modeling Exposure Variables Subject to Limit of Detection," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 16(2), pages 435-458, July.
    8. Ida Kubiszewski & Kenneth Mulder & Diane Jarvis & Robert Costanza, 2022. "Toward better measurement of sustainable development and wellbeing: A small number of SDG indicators reliably predict life satisfaction," Sustainable Development, John Wiley & Sons, Ltd., vol. 30(1), pages 139-148, February.
    9. Georges Steffgen & Philipp E. Sischka & Martha Fernandez de Henestrosa, 2020. "The Quality of Work Index and the Quality of Employment Index: A Multidimensional Approach of Job Quality and Its Links to Well-Being at Work," IJERPH, MDPI, vol. 17(21), pages 1-31, October.
    10. Christopher Kath & Florian Ziel, 2018. "The value of forecasts: Quantifying the economic gains of accurate quarter-hourly electricity price forecasts," Papers 1811.08604, arXiv.org.
    11. J M van Niekerk & M C Vos & A Stein & L M A Braakman-Jansen & A F Voor in ‘t holt & J E W C van Gemert-Pijnen, 2020. "Risk factors for surgical site infections using a data-driven approach," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-14, October.
    12. Joost R. Ginkel, 2020. "Standardized Regression Coefficients and Newly Proposed Estimators for $${R}^{{2}}$$R2 in Multiply Imputed Data," Psychometrika, Springer;The Psychometric Society, vol. 85(1), pages 185-205, March.
    13. Zemin Zheng & Jie Zhang & Yang Li, 2022. "L 0 -Regularized Learning for High-Dimensional Additive Hazards Regression," INFORMS Journal on Computing, INFORMS, vol. 34(5), pages 2762-2775, September.
    14. Gerko Vink & Laurence E. Frank & Jeroen Pannekoek & Stef Buuren, 2014. "Predictive mean matching imputation of semicontinuous variables," Statistica Neerlandica, Netherlands Society for Statistics and Operations Research, vol. 68(1), pages 61-90, February.
    15. Simon Bussy & Mokhtar Z. Alaya & Anne‐Sophie Jannot & Agathe Guilloux, 2022. "Binacox: automatic cut‐point detection in high‐dimensional Cox model with applications in genetics," Biometrics, The International Biometric Society, vol. 78(4), pages 1414-1426, December.
    16. Biagini, Francesca & Groll, Andreas & Widenmann, Jan, 2013. "Intensity-based premium evaluation for unemployment insurance products," Insurance: Mathematics and Economics, Elsevier, vol. 53(1), pages 302-316.
    17. Benedicte Sjo Tislevoll & Monica Hellesøy & Oda Helen Eck Fagerholt & Stein-Erik Gullaksen & Aashish Srivastava & Even Birkeland & Dimitrios Kleftogiannis & Pilar Ayuda-Durán & Laure Piechaczyk & Dagi, 2023. "Early response evaluation by single cell signaling profiling in acute myeloid leukemia," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    18. Tsai, Tsung-Han, 2016. "A Bayesian Approach to Dynamic Panel Models with Endogenous Rarely Changing Variables," Political Science Research and Methods, Cambridge University Press, vol. 4(3), pages 595-620, September.
    19. Leandro C. Hermida & E. Michael Gertz & Eytan Ruppin, 2022. "Predicting cancer prognosis and drug response from the tumor microbiome," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    20. Hung Tong & Cristina Tortora, 2022. "Model-based clustering and outlier detection with missing data," Advances in Data Analysis and Classification, Springer;German Classification Society - Gesellschaft für Klassifikation (GfKl);Japanese Classification Society (JCS);Classification and Data Analysis Group of the Italian Statistical Society (CLADAG);International Federation of Classification Societies (IFCS), vol. 16(1), pages 5-30, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17280-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.