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In situ supramolecular polymerization-enhanced self-assembly of polymer vesicles for highly efficient photothermal therapy

Author

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  • Yannan Liu

    (Shanghai Jiao Tong University)

  • Hao Wang

    (Shenzhen University)

  • Shanlong Li

    (Shanghai Jiao Tong University)

  • Chuanshuang Chen

    (Shanghai Jiao Tong University)

  • Li Xu

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South Campus)

  • Ping Huang

    (Shanghai Jiao Tong University
    Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South Campus)

  • Feng Liu

    (Shanghai Jiao Tong University)

  • Yue Su

    (Shanghai Jiao Tong University)

  • Meiwei Qi

    (Shanghai Jiao Tong University)

  • Chunyang Yu

    (Shanghai Jiao Tong University)

  • Yongfeng Zhou

    (Shanghai Jiao Tong University)

Abstract

Vesicular photothermal therapy agents (PTAs) are highly desirable in photothermal therapy (PTT) for their excellent light-harvesting ability and versatile hollow compartments. However, up to now, the reported vesicular PTAs are generally self-assembled from small molecules like liposomes, and polymer vesicles have seldom been used as PTAs due to the unsatisfactory photothermal conversion efficiency resulting from the irregular packing of chromophores in the vesicle membranes. Here we report a nano-sized polymer vesicle from hyperbranched polyporphyrins with favorable photothermal stability and extraordinarily high photothermal efficiency (44.1%), showing great potential in imaging-guided PTT for tumors through in vitro and in vivo experiments. These excellent properties are attributed to the in situ supramolecular polymerization of porphyrin units inside the vesicle membrane into well-organized 1D monofilaments driven by π–π stacking. We believe the supramolecular polymerization-enhanced self-assembly process reported here will shed a new light on the design of supramolecular materials with new structures and functions.

Suggested Citation

  • Yannan Liu & Hao Wang & Shanlong Li & Chuanshuang Chen & Li Xu & Ping Huang & Feng Liu & Yue Su & Meiwei Qi & Chunyang Yu & Yongfeng Zhou, 2020. "In situ supramolecular polymerization-enhanced self-assembly of polymer vesicles for highly efficient photothermal therapy," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-15427-1
    DOI: 10.1038/s41467-020-15427-1
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    Cited by:

    1. Xianhua Lang & Yingjie Huang & Lirong He & Yixi Wang & Udayabhaskararao Thumu & Zonglin Chu & Wilhelm T. S. Huck & Hui Zhao, 2023. "Mechanosensitive non-equilibrium supramolecular polymerization in closed chemical systems," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Yeqiang Zhou & Fan Fan & Jinling Zhao & Zhaoding Wang & Rui Wang & Yi Zheng & Hang Liu & Chuan Peng & Jianshu Li & Hong Tan & Qiang Fu & Mingming Ding, 2022. "Intrinsically fluorescent polyureas toward conformation-assisted metamorphosis, discoloration and intracellular drug delivery," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Qian Wang & Biyan Lin & Meng Chen & Chengxi Zhao & He Tian & Da-Hui Qu, 2022. "A dynamic assembly-induced emissive system for advanced information encryption with time-dependent security," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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